Evidence map›Paper›PMID 33008138›Full record

ReviewInternational journal of molecular sciences2020

Pathogenesis of Eosinophilic Esophagitis: A Comprehensive Review of the Genetic and Molecular Aspects.

Seohyun Ryu, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Maria Effenberger, Jae Il Shin, Andreas Kronbichler

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 38 citations in OpenAlex.

  1. Trial
  2. Review
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  4. Review
  5. Review
  6. Article
  7. Review
  8. The Dynamic Evolution of Eosinophilic Esophagitis.Diagnostics (Basel, Switzerland) · 2025
    Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Steakhouse syndrome.Clinical case reports · 2021
    Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Seohyun RyuYonsei University College of Medicine, 03722 Seoul, Korea.
Keum Hwa LeeDepartment of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.ORCID 0000-0002-1511-9587
Kalthoum TizaouiLaboratory Microorganismes and Active Biomolecules, Sciences Faculty of Tunis, University Tunis El Manar, 1068 Tunis, Tunisia.
Salvatore TerrazzinoDepartment of Pharmaceutical Sciences and Interdepartmental Research Center of Pharmacogenetics and Pharmacogenomics (CRIFF), University of Piemonte Orientale, 28100 Novara, Italy.ORCID 0000-0002-4909-1121
Sarah CargninDepartment of Pharmaceutical Sciences and Interdepartmental Research Center of Pharmacogenetics and Pharmacogenomics (CRIFF), University of Piemonte Orientale, 28100 Novara, Italy.ORCID 0000-0001-6242-7817
Maria EffenbergerDepartment of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology and Metabolism, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Jae Il ShinDepartment of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.ORCID 0000-0003-2326-1820
Andreas KronbichlerDepartment of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-2945-2946
Yonsei University · KRInnsbruck Medical University · ATUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITTunis University · TN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eosinophilic esophagitis (EoE) is a relatively new condition described as an allergic-mediated disease of the esophagus. Clinically, it is characterized by dysphagia, food impaction, and reflux-like symptoms. Multiple genome-wide association studies (GWAS) have been conducted to identify genetic loci associated with EoE. The integration of numerous studies investigating the genetic polymorphisms in EoE and the Mendelian diseases associated with EoE are discussed to provide insights into the genetic risk of EoE, notably focusing on

Indexed as

Genetic Predisposition to DiseaseCalpainChemokine CCL26CytokinesEosinophilic EsophagitisEsophagusGenome-Wide Association StudyHumansHypersensitivityInterleukin-13Th2 CellsThymic Stromal LymphopoietinTransforming Growth Factor beta1CalpainCAPN14 protein, humanCCL26 protein, humanChemokine CCL26CytokinesIL13 protein, humanInterleukin-13TGFB1 protein, humanThymic Stromal LymphopoietinTransforming Growth Factor beta1TSLP protein, humangenetic susceptibilitypathophysiologypolymorphism

Identifiers

PMID33008138
PMCPMC7582808
OpenAlexW3089470485

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.