ReviewLipids in health and disease2020
The role of leptin in selected skin diseases.
Review in Lipids in health and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- Circadian dysregulation of leptin and its role in skin inflammation and obesity: an integrative perspective.Endocrine · 2026Review
- The Role of dWAT-Immune Crosstalk in Hair Follicle Microenvironment in Hair Regeneration.The Journal of dermatology · 2026Review
- Microbial Biotransformation of Chicory byInternational journal of molecular sciences · 2025Article
- Weight loss, disease activity, and patient reported outcomes in patients with musculoskeletal and autoimmune diseases taking weight loss medications: a retrospective cohort study.Seminars in arthritis and rheumatism · 2025Article
- Psoriasis, stem cells, and obesity: metabolic exploration for therapeutics.Journal of medicine and life · 2025Review
- Intermittent methionine restriction and selenium supplementation protect against inflammation and the development of dermatitis.Journal of inflammation (London, England) · 2025Article
- Adipokines and Adipose Tissue: The Role and Use of Sodium-Glucose Co-Transporter-2 (SGLT-2) Inhibitors in Patients with Diabetes or Heart Failure.Biomedicines · 2025Review
- Review
- Psoriasis: an emerging risk factor for ischemic stroke?Frontiers in neurology · 2025Review
- A multidimensional analysis of prognostic factors in atopic dermatitis.Frontiers in medicine · 2025Review
- Unveiling the impact of hypodermis on gene expression for advancing bioprinted full-thickness 3D skin models.Communications biology · 2024Article
- Association of Obesity and Bariatric Surgery on Hair Health.Medicina (Kaunas, Lithuania) · 2024Review
- Mendelian randomization analyses reveal no genetic causal effects of major adipokines on systemic lupus erythematosus.PloS one · 2024Article
- Adipose Tissue, Regeneration, and Skin Health: The Next Regenerative Frontier.Aesthetic surgery journal. Open forum · 2024Article
- Insights into Nutritional Strategies in Psoriasis.Nutrients · 2023Review
- High tissue-sodium associates with systemic inflammation and insulin resistance in obese individuals.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2023Article
- Obesity-induced immunological effects on the skin.Skin health and disease · 2023Review
- Obesity and Wound Healing: Focus on Mesenchymal Stem Cells.Life (Basel, Switzerland) · 2023Review
- A Genomic Approach to Identify the Different between Acute and Chronic UVB Exposures in the Causation of Inflammation and Cancer.Journal of cancer prevention · 2022Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leptin is an adipokine, adipocyte-derived compound, which acts both as a hormone and cytokine. It is mainly synthesized by adipocytes of white adipose tissue. Leptin possesses pleiotropic functions including, among others, stimulation of angiogenesis and production of proinflammatory cytokines. The various types of leptin activity are related to the wide distribution of leptin receptors. This adipokine acts by activating intracellular signaling cascades such as JAKs (Janus kinases), STATs (signal transducers and activators of transcription), and others.In a course of obesity, an increased serum level of leptin coexists with tissue receptor resistance. It has been reported that enhanced leptin levels, leptin receptor impairment, and dysfunction of leptin signaling can influence skin and hair. The previous studies revealed the role of leptin in wound healing, hair cycle, and pathogenesis of skin diseases like psoriasis, lupus erythematosus, and skin cancers. However, the exact mechanism of leptin's impact on the skin is still under investigation. Herein, we present the current knowledge concerning the role of leptin in psoriasis and selected skin diseases.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.