Evidence map›Paper›PMID 33008713›Full record

ReviewTrends in microbiology2021

Ins and Outs of Reovirus: Vesicular Trafficking in Viral Entry and Egress.

Alexa N Roth, Pavithra Aravamudhan, Isabel Fernández de Castro, Raquel Tenorio, Cristina Risco, Terence S Dermody

Abstract readReview
In one paragraph

Review in Trends in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. Article
  3. Alpha-Glucosidase ofViruses · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Virion aggregation shapes infection dynamics and evolutionary potential.bioRxiv : the preprint server for biology · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Transcriptomics of early responses to purifiedFrontiers in immunology · 2024
    Article
  14. Article
  15. NgR1 binding to reovirus reveals an unusual bivalent interaction and a new viral attachment protein.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  16. Review
  17. Exosomal transmission of viruses, a two-edged biological sword.Cell communication and signaling : CCS · 2023
    Review
  18. Article
  19. Article
  20. ICTV Virus Taxonomy Profile:The Journal of general virology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexa N RothDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Microbial Pathogenesis, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Pavithra AravamudhanDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Microbial Pathogenesis, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Isabel Fernández de CastroCell Structure Laboratory, National Center for Biotechnology, CNB-CSIC, Campus UAM, Cantoblanco, 28049, Madrid, Spain.
Raquel TenorioCell Structure Laboratory, National Center for Biotechnology, CNB-CSIC, Campus UAM, Cantoblanco, 28049, Madrid, Spain.
Cristina RiscoCell Structure Laboratory, National Center for Biotechnology, CNB-CSIC, Campus UAM, Cantoblanco, 28049, Madrid, Spain.
Terence S DermodyDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Microbial Pathogenesis, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: terence.dermody@chp.edu.

Funding

CELL ENTRY OF REOVIRUSR01AI032539 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI TERENCE S. DERMODY · 1998 to 2026
$12.3M
Immunology of Infectious DiseaseT32AI060525 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JoAnne L. Flynn · 2005 to 2026
$5.3M
NIAID NIH HHS R01 AI032539NIAID NIH HHS T32 AI060525
6 · The paper itself

Abstract

Cell entry and egress are essential steps in the viral life cycle that govern pathogenesis and spread. Mammalian orthoreoviruses (reoviruses) are nonenveloped viruses implicated in human disease that serve as tractable models for studies of pathogen-host interactions. In this review we discuss the function of intracellular vesicular transport systems in reovirus entry, trafficking, and egress and comment on shared themes for diverse viruses. Designing strategic therapeutic interventions that impede these steps in viral replication requires a detailed understanding of mechanisms by which viruses coopt vesicular trafficking. We illuminate such targets, which may foster development of antiviral agents.

Indexed as

Host-Pathogen InteractionsVirus InternalizationVirus ReleaseAnimalsBiological TransportHumansMammalsReoviridaemammalian orthoreovirusnonlytic egressvesicular traffickingviral egressviral entry

Identifiers

PMID33008713
PMCPMC7523517

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.