Evidence map›Paper›PMID 33009377›Full record

ArticleNature communications2020

Remote ischemic conditioning counteracts the intestinal damage of necrotizing enterocolitis by improving intestinal microcirculation.

Yuhki Koike, Bo Li, Niloofar Ganji, Haitao Zhu, Hiromu Miyake, Yong Chen, Carol Lee, Maarten Janssen Lok, Carlos Zozaya, Ethan Lau and 14 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05279664 (RIC-NEC Phase II Feasibility Randomized Controlled Trial), which is not on this map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05279664 phase2active not recruitingnot on this mapstarted 2023, after this paper: background citation

RIC-NEC Phase II Feasibility Randomized Controlled Trial: Remote Ischemic Conditioning in Necrotizing Enterocolitis

TypeinterventionalSponsorThe Hospital for Sick ChildrenRan2023 to 2026Enrolled78ConditionsNecrotizing EnterocolitisArmsRemote ischemic conditioning (RIC) + Standard of Care for NEC, Standard of Care for NEC
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 91 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Remote ischaemic conditioning in necrotising enterocolitis: a phase I feasibility and safety study.Archives of disease in childhood. Fetal and neonatal edition · 2023
    Trial
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. The fifty billion dollar question: does formula cause necrotizing enterocolitis?Journal of perinatology : official journal of the California Perinatal Association · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Prevention Strategies and Management of Necrotizing Enterocolitis.Current treatment options in pediatrics · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 4 institutions in 3 countries.

Yuhki Koike *Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.
Bo Li *Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-8298-8344
Niloofar Ganji *Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.
Haitao Zhu *Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.
Hiromu MiyakeTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.
Yong ChenTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.
Carol LeeTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.
Maarten Janssen LokTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.
Carlos ZozayaDivision of Neonatology, The Hospital for Sick Children, Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-0062-9258
Ethan LauTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.
Dorothy LeeTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.
Sinobol ChusilpTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.ORCID http://orcid.org/0000-0001-6473-0385
Zhen ZhangTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.
Masaya YamotoTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.
Richard Y WuCell Biology Program, Research Institute, Division of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children, Toronto, ON, Canada.
Mikihiro InoueDepartments of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Japan.
Keiichi UchidaDepartments of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Japan.
Masato KusunokiDepartments of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Japan.
Paul Delgado-OlguinTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-5355-247X
Luc MertensThe Labatt Family Heart Center, Cardiology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Alan DanemanDepartment of Diagnostic Imaging, Division of Nuclear Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Simon EatonUCL Great Ormond Street Institute of Child Health, London, UK.ORCID http://orcid.org/0000-0003-0892-9204
Philip M ShermanCell Biology Program, Research Institute, Division of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-4733-6690
Agostino PierroTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada. agostino.pierro@sickkids.ca.ORCID http://orcid.org/0000-0002-6742-6570
Hospital for Sick Children · CAUniversity of Toronto · CAMie University · JPGreat Ormond Street Hospital · GB

Funding

CIHR 162208CIHR 353857CIHR PJT-149046
6 · The paper itself

Abstract

Necrotizing enterocolitis (NEC) is a devastating disease of premature infants with high mortality rate, indicating the need for precision treatment. NEC is characterized by intestinal inflammation and ischemia, as well derangements in intestinal microcirculation. Remote ischemic conditioning (RIC) has emerged as a promising tool in protecting distant organs against ischemia-induced damage. However, the effectiveness of RIC against NEC is unknown. To address this gap, we aimed to determine the efficacy and mechanism of action of RIC in experimental NEC. NEC was induced in mouse pups between postnatal day (P) 5 and 9. RIC was applied through intermittent occlusion of hind limb blood flow. RIC, when administered in the early stages of disease progression, decreases intestinal injury and prolongs survival. The mechanism of action of RIC involves increasing intestinal perfusion through vasodilation mediated by nitric oxide and hydrogen sulfide. RIC is a viable and non-invasive treatment strategy for NEC.

Indexed as

MicrocirculationAnimalsEnterocolitis, NecrotizingEnterocytesHumansHypoxiaIntestinal MucosaIntestinesIschemiaMice, Inbred C57BLMicrovilli

Identifiers

PMID33009377
PMCPMC7532542
OpenAlexW3089553153

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.