Evidence map›Paper›PMID 33010162›Full record

ArticleEuropean heart journal. Cardiovascular pharmacotherapy2021

REDUCE-IT INTERIM: accumulation of data across prespecified interim analyses to final results.

Brian Olshansky, Deepak L Bhatt, Michael Miller, Ph Gabriel Steg, Eliot A Brinton, Terry A Jacobson, Steven B Ketchum, Ralph T Doyle, Rebecca A Juliano, Lixia Jiao and 7 more

Registry-linked trialAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal. Cardiovascular pharmacotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT01492361. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01492361 phase3completed

Evaluation of the Effect of AMR101 on Cardiovascular Health and Mortality in Hypertriglyceridemic Patients With Cardiovascular Disease or at High Risk for Cardiovascular Disease: REDUCE-IT (Reduction of Cardiovascular Events With EPA - Intervention Trial)

Ran2011Enrolled8,179Registered outcomes10Posted comparisons10ConditionsCardiovascular DiseasesArmsAMR101, Placebo, Statin therapy
PMID 30415628PMID 35027114PMID 34620410PMID 28294373PMID 30898607PMID 31439224PMID 31707829PMID 34710343PMID 34706555PMID 33148016other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Trial
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  4. Trial
  5. Article
  6. Do patients benefit from omega-3 fatty acids?Cardiovascular research · 2024
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Brian OlshanskyDivision of Cardiology, Department of Internal Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52240, USA.ORCID 0000-0002-6044-045X
Deepak L BhattBrigham and Women's Hospital Heart & Vascular Center, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.ORCID 0000-0002-1278-6245
Michael MillerCardiovascular Medicine, Epidemiology & Public Health, University of Maryland School of Medicine, 110 South Paca St., Baltimore, MD 21201, USA.ORCID 0000-0001-5475-6813
Ph Gabriel StegFrench Alliance for Cardiovascular Trials, Hôpital Bichat, Assistance Publique, - Hôpitaux de Paris, 46 rue Henri Huchard, Paris 75018, France.ORCID 0000-0001-6896-2941
Eliot A BrintonUtah Lipid Center, 421 Wakara Way, Salt Lake City, UT 84108, USA.ORCID 0000-0002-9807-4010
Terry A JacobsonOffice of Health Promotion and Disease Prevention, Emory University School of Medicine, 49 Jesse Hill Jr. Dr. SE, Atlanta 30303, GA, USA.ORCID 0000-0002-9926-2179
Steven B KetchumAmarin Pharma, Inc., Inc. 440 Route 22, Bridgewater, NJ 08807, USA.ORCID 0000-0002-8192-1711
Ralph T DoyleAmarin Pharma, Inc., Inc. 440 Route 22, Bridgewater, NJ 08807, USA.ORCID 0000-0003-4068-7778
Rebecca A JulianoAmarin Pharma, Inc., Inc. 440 Route 22, Bridgewater, NJ 08807, USA.ORCID 0000-0002-3714-6084
Lixia JiaoAmarin Pharma, Inc., Inc. 440 Route 22, Bridgewater, NJ 08807, USA.ORCID 0000-0001-7003-4925
Craig GranowitzAmarin Pharma, Inc., Inc. 440 Route 22, Bridgewater, NJ 08807, USA.ORCID 0000-0003-1533-3679
Jean-Claude TardifMontreal Heart Institute, Université de Montréal, 5000, Bélanger St., Montreal, Quebec H1T 1C8, Canada.ORCID 0000-0002-8200-8983
Cyrus MehtaCytel, Inc. 675 Massachusetts Ave., Cambridge, MA 02139, USA.ORCID 0000-0003-0724-3104
Rajat MukherjeeCytel, Inc. 675 Massachusetts Ave., Cambridge, MA 02139, USA.ORCID 0000-0001-7905-2767
Christie M BallantyneCardiology and Cardiovascular Research, Houston Methodist DeBakey Heart and Vascular Center, Baylor College of Medicine, 6655 Travis St., Houston, TX 77030, USA.ORCID 0000-0002-6432-1730
Mina K ChungCardiac Pacing and Electrophysiology, Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Lerner College of Medicine of Case Western Reserve University, 9500 Euclid Avenue, Cleveland, OH 44195, USA.ORCID 0000-0002-7835-6045
REDUCE-IT Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID33010162
PMCPMC8141294

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.