Evidence map›Paper›PMID 33012445›Full record

ReviewClinics in liver disease2020

Lifestyle and Environmental Approaches for the Primary Prevention of Hepatocellular Carcinoma.

Tracey G Simon, Andrew T Chan

Open access · greenAbstract readReview
In one paragraph

Review in Clinics in liver disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Tracey G SimonDivision of Gastroenterology, GRJ-825C, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA; Harvard Medical School, Boston, MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA.
Andrew T ChanDivision of Gastroenterology, GRJ-825C, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA; Harvard Medical School, Boston, MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Broad Institute, Boston, MA, USA; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: achan@mgh.harvard.edu.
Massachusetts General Hospital · US

Funding

Precision Prevention Research ProgramR35CA253185 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Andrew T Chan · 2020 to 2026
$6.9M
Aspirin and Novel Lipid Mediators in Nonalcoholic Fatty Liver DiseaseK23DK122104 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI SIMON, TRACEY · 2019 to 2023
$1.1M
Mentored Patient-Oriented Research in Digestive DiseasesK24DK098311 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHAN, ANDREW T · 2013 to 2017
$930k
NCI NIH HHS R35 CA253185NIDDK NIH HHS K23 DK122104NIDDK NIH HHS K24 DK098311
6 · The paper itself

Abstract

Patients with chronic liver disease are at increased risk of developing hepatocellular carcinoma (HCC). Most patients diagnosed with HCC have limited treatment options and a poor overall prognosis, with a 5-year survival less than 15%. Preventing the development of HCC represents the most important strategy. However, current guidelines lack specific recommendations for primary prevention. Lifestyle factors may be central in the pathogenesis of HCC, and primary prevention strategies focused on lifestyle modification could represent an important approach to the prevention of HCC. Both experimental and epidemiologic studies have identified promising chemopreventive agents for the primary prevention of HCC.

Indexed as

Primary PreventionAlcohol DrinkingAspirinCarcinoma, HepatocellularChronic DiseaseDiabetes Mellitus, Type 2DietHumansHydroxymethylglutaryl-CoA Reductase InhibitorsLiver DiseasesLiver NeoplasmsObesityPlatelet Aggregation InhibitorsRisk Reduction BehaviorAspirinHydroxymethylglutaryl-CoA Reductase InhibitorsPlatelet Aggregation InhibitorsCancer preventionChemopreventionHepatocellular carcinomaLifestyleModifiable risk factor

Identifiers

PMID33012445
PMCPMC7536356
OpenAlexW3080996429

What Socratic holds

Texttitle and abstract
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.