ReviewFrontiers in bioengineering and biotechnology2020
Bioengineering of Microalgae: Recent Advances, Perspectives, and Regulatory Challenges for Industrial Application.
Review in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed.
- Process intensification for the protein production from microalgae: a comprehensive review.Bioresources and bioprocessing · 2026Review
- Precision Microalgae: A New Conceptual Framework for Bioengineering Applications.Bioengineering (Basel, Switzerland) · 2026Review
- Novel biopolymer in extracellular substances from the filamentous cyanobacterium Limnothrix sp.Applied biochemistry and biotechnology · 2026Article
- Marine Algae as Sustainable Platforms for the Green Synthesis of Metal Nanoparticles.ACS omega · 2026Review
- Content, Ratio and Productivity of Amphidinols in Wild-Type and Mutagenized Strains ofMarine drugs · 2026Article
- Mechanistic insights of smart biofilms in environmental bio-monitoring: from growth to detection.Microbial cell factories · 2026Review
- Engineering bidirectional chloroplast promoters for tunable co-expression of multiple genes in microalgae (Chlamydomonas reinhardtii).Communications biology · 2026Article
- Genome-Wide Characterization and Expression Analysis ofBiology · 2025Article
- Valorization ofACS omega · 2025Article
- Co-Culture of Cyanobacteria and Rhizobia, Increasing Biomass Under Nitrogen-Starvation Conditions.Applied biochemistry and biotechnology · 2025Article
- Microalgae: Green Engines for Achieving Carbon Sequestration, Circular Economy, and Environmental Sustainability-A Review Based on Last Ten Years of Research.Bioengineering (Basel, Switzerland) · 2025Review
- Comparative genomic insights into ecological adaptations and evolutionary dynamics of Trebouxiophyceae algae.BMC genomics · 2025Article
- Beyond Cutting: CRISPR-Driven Synthetic Biology Toolkit for Next-Generation Microalgal Metabolic Engineering.International journal of molecular sciences · 2025Review
- Upcycling food waste for microalgae cultivation toward lipid production in a closed-loop and system-integrated circular bioeconomy.Biotechnology for biofuels and bioproducts · 2025Review
- Progress and prospects in metabolic engineering approaches for isoprenoid biosynthesis in microalgae.Biotechnology for biofuels and bioproducts · 2025Review
- In Vitro Culture, Genetic Transformation and the Production of Biopharmaceuticals in Microalgae.International journal of molecular sciences · 2025Review
- Enhancing diesel engine performance and emissions with N-Butanol enhanced biodiesel derived from Scenedesmus obliquus algae.Scientific reports · 2025Article
- Impact of heterologous expression of Cannabis sativa tetraketide synthase on Phaeodactylum tricornutum metabolic profile.Biotechnology for biofuels and bioproducts · 2025Article
- Benchmarking commercially available value-added fractions with potential for production via microalgae-based biorefineries: is it worth it?Biotechnology for biofuels and bioproducts · 2025Review
- Regulation of nucleus-encoded trans-acting factors allows orthogonal fine-tuning of multiple transgenes in the chloroplast of Chlamydomonas reinhardtii.Plant biotechnology journal · 2025Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microalgae, due to their complex metabolic capacity, are being continuously explored for nutraceuticals, pharmaceuticals, and other industrially important bioactives. However, suboptimal yield and productivity of the bioactive of interest in local and robust wild-type strains are of perennial concerns for their industrial applications. To overcome such limitations, strain improvement through genetic engineering could play a decisive role. Though the advanced tools for genetic engineering have emerged at a greater pace, they still remain underused for microalgae as compared to other microorganisms. Pertaining to this, we reviewed the progress made so far in the development of molecular tools and techniques, and their deployment for microalgae strain improvement through genetic engineering. The recent availability of genome sequences and other omics datasets form diverse microalgae species have remarkable potential to guide strategic momentum in microalgae strain improvement program. This review focuses on the recent and significant improvements in the omics resources, mutant libraries, and high throughput screening methodologies helpful to augment research in the model and non-model microalgae. Authors have also summarized the case studies on genetically engineered microalgae and highlight the opportunities and challenges that are emerging from the current progress in the application of genome-editing to facilitate microalgal strain improvement. Toward the end, the regulatory and biosafety issues in the use of genetically engineered microalgae in commercial applications are described.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.