ArticlePLoS pathogens2020
Novel Babesia bovis exported proteins that modify properties of infected red blood cells.
Article in PLoS pathogens, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Plasmepsins as Antimalarial Drug Targets-Then, Now, and the Future.Medicinal research reviews · 2026Review
- Sorbitol-Induced Synchronisation of Babesia duncani and Assessment of Linoleic Acid Effect on Parasite-Derived Vesicles.Parasite immunology · 2025Article
- ves1α genes expression is the major determinant of Babesia bovis-infected erythrocytes cytoadhesion to endothelial cells.PLoS pathogens · 2025Article
- Critical role of Babesia bovis spherical body protein 3 in ridge formation on infected red blood cells.PLoS pathogens · 2024Article
- Chromosome-level genome assembly of Babesia caballi reveals diversity of multigene families among Babesia species.BMC genomics · 2023Article
- Whole genome sequence and diversity in multigene families ofFrontiers in cellular and infection microbiology · 2023Article
- Advances in understanding red blood cell modifications by Babesia.PLoS pathogens · 2022Review
- Comparative single-cell transcriptional atlases of Babesia species reveal conserved and species-specific expression profiles.PLoS biology · 2022Article
- Recent Advances in Molecular Genetic Tools forVeterinary sciences · 2021Review
- Plasmepsin-like Aspartyl Proteases inPathogens (Basel, Switzerland) · 2021Article
- Isolation of viable Babesia bovis merozoites to study parasite invasion.Scientific reports · 2021Article
- Applying Machine Learning to Predict the Exportome of Bovine and CaninePathogens (Basel, Switzerland) · 2021Article
- Promises and Pitfalls of Parasite Patch-clamp.Trends in parasitology · 2021Review
- Transport mechanisms at the malaria parasite-host cell interface.PLoS pathogens · 2021Review
- Discovering the Potent Inhibitors AgainstFrontiers in veterinary science · 2021Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Babesia bovis causes a pathogenic form of babesiosis in cattle. Following invasion of red blood cells (RBCs) the parasite extensively modifies host cell structural and mechanical properties via the export of numerous proteins. Despite their crucial role in virulence and pathogenesis, such proteins have not been comprehensively characterized in B. bovis. Here we describe the surface biotinylation of infected RBCs (iRBCs), followed by proteomic analysis. We describe a multigene family (mtm) that encodes predicted multi-transmembrane integral membrane proteins which are exported and expressed on the surface of iRBCs. One mtm gene was downregulated in blasticidin-S (BS) resistant parasites, suggesting an association with BS uptake. Induced knockdown of a novel exported protein encoded by BBOV_III004280, named VESA export-associated protein (BbVEAP), resulted in a decreased growth rate, reduced RBC surface ridge numbers, mis-localized VESA1, and abrogated cytoadhesion to endothelial cells, suggesting that BbVEAP is a novel virulence factor for B. bovis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.