Evidence map›Paper›PMID 33020113›Full record

ArticleBMJ open respiratory research2020

Investigating outcome measures for assessing airway clearance techniques in adults with cystic fibrosis: protocol of a single-centre randomised controlled crossover trial.

Gemma Stanford, Jane C Davies, Omar Usmani, Winston Banya, Susan Charman, Mandy Jones, Nicholas J Simmonds, Diana Bilton

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open respiratory research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02721498 (Improving Outcome Measures For Physiotherapy Trials of Airway Clearance in Adults With Cystic Fibrosis), which is not on this map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02721498 nacompletednot on this map

Improving Outcome Measures For Physiotherapy Trials of Airway Clearance in Adults With Cystic Fibrosis

TypeinterventionalSponsorRoyal Brompton & Harefield NHS Foundation TrustRan2016 to 2021Enrolled68ConditionsCystic FibrosisArmsAirway clearance session using the Active Cycle of Breathing Techniques (ACBT), Rest period
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Active cycle of breathing technique for cystic fibrosis.The Cochrane database of systematic reviews · 2023
    Pooled it
  3. Pooled it
  4. The feasibility of using electrical impedance tomography to guide positive pressure airway clearance in children with cystic fibrosis and tracheobronchomalacia.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Oscillometry of the respiratory system: a translational opportunity not to be missed.American journal of physiology. Lung cellular and molecular physiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Gemma StanfordAdult Cystic Fibrosis, Royal Brompton Hospital, London, UK.ORCID http://orcid.org/0000-0001-6967-6883
Jane C DaviesNational Heart and Lung Institute, Imperial College London, London, UK.
Omar UsmaniNational Heart and Lung Institute, Imperial College London, London, UK.
Winston BanyaNational Heart and Lung Institute, Imperial College London, London, UK.
Susan CharmanCystic Fibrosis Trust, London, UK.
Mandy JonesDepartment of Health Sciences, College of Health, Medicine and Life Scientists, Brunel University London, London, UK.
Nicholas J SimmondsAdult Cystic Fibrosis, Royal Brompton Hospital, London, UK n.simmonds@imperial.ac.uk.
Diana BiltonRespiratory Medicine, Royal Brompton Hospital, London, UK.
Royal Brompton Hospital · GBBrunel University of London · GBCystic Fibrosis Trust · GB

Funding

Department of Health CDRF-2014-05-055
6 · The paper itself

Abstract

introductionAirway clearance techniques (ACTs) are a gold standard of cystic fibrosis management; however, the majority of research evidence for their efficacy is of low standard; often attributed to the lack of sensitivity from outcome measures (OMs) used historically. This randomised controlled trial (RCT) investigates these standard OMs (sputum weight, forced expiratory volume in 1 s) and new OMs (electrical impedance tomography (EIT), multiple breath washout (MBW) and impulse oscillometry (IOS)) to determine the most useful measures of ACT. METHODS AND ANALYSIS: This is a single-centre RCT with crossover design. Participants perform MBW, IOS and spirometry, and then are randomised to either rest or supervised ACT lasting 30-60 min. MBW, IOS and spirometry are repeated immediately afterwards. EIT and sputum are collected during rest/ACT. On a separate day, the OMs are performed with the other intervention. Primary endpoint is difference in change in OMs before and after ACT/rest. Sample size was calculated with 80% power and significance of 5% for each OM (target n=64). ETHICS AND DISSEMINATION: Ethics approval was gained from the London-Chelsea Research Ethics Committee (reference 16/LO/0995, project ID 154635). Dissemination will involve scientific conference presentation and publication in a peer-reviewed journal. TRIAL REGISTRATION NUMBERS: ISRCTN11220163 and NCT02721498.

Indexed as

Cystic FibrosisAdultCross-Over StudiesForced Expiratory VolumeHumansOutcome Assessment, Health CareRandomized Controlled Trials as TopicSputumcystic fibrosisrespiratory measurement

Identifiers

PMID33020113
PMCPMC7537140
OpenAlexW3090026987

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.