Evidence map›Paper›PMID 33020153›Full record

ArticleAntimicrobial agents and chemotherapy2020

Piperaquine Exposure Is Altered by Pregnancy, HIV, and Nutritional Status in Ugandan Women.

Emma Hughes, Marjorie Imperial, Erika Wallender, Richard Kajubi, Liusheng Huang, Prasanna Jagannathan, Nan Zhang, Abel Kakuru, Paul Natureeba, Moses W Mwima and 11 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Trial
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 2 countries.

Emma HughesDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA emma.hughes@ucsf.edu rada.savic@ucsf.edu.
Marjorie ImperialDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA.
Erika WallenderDepartment of Clinical Pharmacy, University of California, San Francisco, California, USA.ORCID 0000-0003-1166-1587
Richard KajubiInfectious Disease Research Collaboration, Kampala, Uganda.
Liusheng HuangDepartment of Clinical Pharmacy, University of California, San Francisco, California, USA.
Prasanna JagannathanDepartment of Medicine, Stanford University, California, USA.ORCID 0000-0001-6305-758X
Nan ZhangDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA.
Abel KakuruInfectious Disease Research Collaboration, Kampala, Uganda.
Paul NatureebaInfectious Disease Research Collaboration, Kampala, Uganda.
Moses W MwimaInfectious Disease Research Collaboration, Kampala, Uganda.
Mary MuhindoInfectious Disease Research Collaboration, Kampala, Uganda.
Norah MwebazaDepartment of Pharmacology & Therapeutics, Makerere University College of Health Sciences, Kampala, Uganda.
Tamara D ClarkDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.
Bishop OpiraInfectious Disease Research Collaboration, Kampala, Uganda.
Miriam NakalembeInfectious Disease Research Collaboration, Kampala, Uganda.
Diane HavlirDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.
Moses KamyaInfectious Disease Research Collaboration, Kampala, Uganda.
Philip J RosenthalDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0002-7953-7622
Grant DorseyDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.
Francesca AweekaDepartment of Clinical Pharmacy, University of California, San Francisco, California, USA.
Radojka M SavicDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA emma.hughes@ucsf.edu rada.savic@ucsf.edu.ORCID 0000-0003-3143-5579
University of California, San Francisco · USInfectious Diseases Research Collaboration · UGMakerere University · UGStanford University · US

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi · 1988 to 2026
$93.6M
ZIDOVUDINE &LAMIVUDINE &NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFM01RR001271 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KESSLER, DAVID A · 1985 to 2006
$22.7M
The immunologic consequences of prenatal exposure to malariaP01HD059454 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HAVLIR, DIANE V · 2008 to 2017
$22.6M
UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
Pharmacological insights into antimalarial exposure, clinical outcomes, and drug resistance in AfricaR01AI117001 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AWEEKA, FRANCESCA T., ROSENTHAL, PHILIP JON · 2015 to 2024
$7.1M
NCRR NIH HHS M01 RR001271NIAID NIH HHS P30 AI027763NIAID NIH HHS R01 AI117001NICHD NIH HHS P01 HD059454NIDDK NIH HHS P30 DK098722
6 · The paper itself

Abstract

Dihydroartemisinin-piperaquine (DHA-PQ) provides highly effective therapy and chemoprevention for malaria in pregnant African women. PQ concentrations of >10.3 ng/ml have been associated with reduced maternal parasitemia, placental malaria, and improved birth outcomes. We characterized the population pharmacokinetics (PK) of PQ in a

Indexed as

AntimalarialsHIV InfectionsQuinolinesDrug CombinationsFemaleHumansMolecular Diagnostic TechniquesNucleic Acid Amplification TechniquesNutritional StatusPiperazinesPregnancyUgandaAntimalarialsDrug CombinationspiperaquinePiperazinesQuinolinesdihydroartemisinin-piperaquinedrug-drug interactionsmalaria preventionpharmacokineticspopulation pharmacokineticspregnancy

Identifiers

PMID33020153
PMCPMC7674024
OpenAlexW3091739255

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.