ArticleBritish journal of cancer2021
Searching for causal relationships of glioma: a phenome-wide Mendelian randomisation study.
Article in British journal of cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- The causal relationship between multiple cardiovascular diseases and glioblastoma: A Mendelian randomization study.Medicine · 2026Article
- Systematic decoding of functional enhancer connectomes and risk variants in human glioma.Nature cell biology · 2025Article
- Glioma raises periodontitis risk via CD8 upregulation on NKT cells: a Mendelian randomization study.Discover oncology · 2025Article
- Integrating machine learning with mendelian randomization for unveiling causal gene networks in glioblastoma multiforme.Discover oncology · 2025Article
- Article
- Sjögren's syndrome and Parkinson's disease: a bidirectional Mendelian randomization study.Frontiers in genetics · 2024Article
- Design and quality control of large-scale two-sample Mendelian randomization studies.International journal of epidemiology · 2023Article
- Article
- Predictive models and survival analysis of postoperative mental health disturbances in adult glioma patients.Frontiers in oncology · 2023Article
- Relationship between genetically determined telomere length and glioma risk.Neuro-oncology · 2022Article
- Search for AL amyloidosis risk factors using Mendelian randomization.Blood advances · 2021Article
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6 authors.
Funding
Abstract
backgroundThe aetiology of glioma is poorly understood. Summary data from genome-wide association studies (GWAS) can be used in a Mendelian randomisation (MR) phenome-wide association study (PheWAS) to search for glioma risk factors.
methodsWe performed an MR-PheWAS analysing 316 phenotypes, proxied by 8387 genetic variants, and summary genetic data from a GWAS of 12,488 glioma cases and 18,169 controls. Causal effects were estimated under a random-effects inverse-variance-weighted (IVW-RE) model, with robust adjusted profile score (MR-RAPS), weighted median and mode-based estimates computed to assess the robustness of findings. Odds ratios per one standard deviation increase in each phenotype were calculated for all glioma, glioblastoma (GBM) and non-GBM tumours.
resultsNo significant associations (P < 1.58 × 10
conclusionsOur study provides further insight into the aetiological basis of glioma for which published data have been mixed.
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