Evidence map›Paper›PMID 33022781›Full record

ReviewAnnals of the New York Academy of Sciences2021

SARS-CoV-2 infection, COVID-19 pathogenesis, and exposure to air pollution: What is the connection?

Brittany Woodby, Michelle M Arnold, Giuseppe Valacchi

Open access · bronzeAbstract readReview
In one paragraph

Review in Annals of the New York Academy of Sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 1 pooled it
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 1 synthesis or guideline pooled it, 164 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Climate Change and the Future of Allergies and Asthma.Current allergy and asthma reports · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Relationship between COVID-19 Cases and Environmental Contaminants in Quito, Ecuador.International journal of environmental research and public health · 2024
    Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Is Pollution the Primary Driver of Infectious Syndemics?Pathogens (Basel, Switzerland) · 2024
    Review
  19. Article
  20. Article

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Brittany WoodbyAnimal Science Department, Plants for Human Health Institute, N.C. Research Campus, North Carolina State University, Kannapolis, North Carolina.
Michelle M ArnoldDepartment of Microbiology and Immunology, Center for Molecular and Tumor Virology, Louisiana State University Health Sciences Center, Shreveport, Louisiana.
Giuseppe ValacchiAnimal Science Department, Plants for Human Health Institute, N.C. Research Campus, North Carolina State University, Kannapolis, North Carolina.
Louisiana State University Health Sciences Center Shreveport · USNorth Carolina Agricultural and Technical State University · USUniversity of Ferrara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exposure to air pollutants has been previously associated with respiratory viral infections, including influenza, measles, mumps, rhinovirus, and respiratory syncytial virus. Epidemiological studies have also suggested that air pollution exposure is associated with increased cases of SARS-CoV-2 infection and COVID-19-associated mortality, although the molecular mechanisms by which pollutant exposure affects viral infection and pathogenesis of COVID-19 remain unknown. In this review, we suggest potential molecular mechanisms that could account for this association. We have focused on the potential effect of exposure to nitrogen dioxide (NO

Indexed as

PandemicsSARS-CoV-2Adaptive ImmunityAir PollutantsAir PollutionCOVID-19Host Microbial InteractionsHumansImmunity, InnateModels, BiologicalParticulate MatterReceptors, VirusRespiratory SystemToll-Like ReceptorsVirus InternalizationVirus ReplicationAir PollutantsParticulate MatterReceptors, VirusToll-Like Receptorsair pollutioncoronavirusnitrogen dioxideozoneparticulate matterviral infection

Identifiers

PMID33022781
PMCPMC7675684
OpenAlexW3091726314

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.