Evidence map›Paper›PMID 33022979›Full record

ReviewInternational journal of molecular sciences2020

Susceptibility Factors in Chronic Lung Inflammatory Responses to Engineered Nanomaterials.

Dorothy J You, James C Bonner

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Cellular andThe journal of physical chemistry. B · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Micro- and Nanosized Substances Cause Different Autophagy-Related Responses.International journal of molecular sciences · 2021
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Dorothy J YouToxicology Program, Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695, USA.
James C BonnerToxicology Program, Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695, USA.
North Carolina State University · US

Funding

TRAINING IN BIOCHEMICAL AND ENVIRONMENTAL TOXICOLOGYT32ES007046 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Seth William Kullman · 1985 to 2026
$5.1M
Genetic Susceptibility to Nanoparticle-Induced Respiratory DiseaseR01ES020897 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI BONNER, JAMES CHRISTOPHER · 2012 to 2017
$1.7M
National Science Foundation 15-022NIEHS NIH HHS R01ES020897NIEHS NIH HHS T32ES007046
6 · The paper itself

Abstract

Engineered nanomaterials (ENMs) are products of the emerging nanotechnology industry and many different types of ENMs have been shown to cause chronic inflammation in the lungs of rodents after inhalation exposure, suggesting a risk to human health. Due to the increasing demand and use of ENMs in a variety of products, a careful evaluation of the risks to human health is urgently needed. An assessment of the immunotoxicity of ENMs should consider susceptibility factors including sex, pre-existing diseases, deficiency of specific genes encoding proteins involved in the innate or adaptive immune response, and co-exposures to other chemicals. This review will address evidence from experimental animal models that highlights some important issues of susceptibility to chronic lung inflammation and systemic immune dysfunction after pulmonary exposure to ENMs.

Indexed as

AnimalsHumansInflammationInhalation ExposureLungNanostructuresPneumoniachronic inflammationengineered nanomaterialslung inflammation.susceptibility

Identifiers

PMID33022979
PMCPMC7582686
OpenAlexW3091235524

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.