ReviewWorld journal of clinical cases2020
Hepatic epithelioid hemangioendothelioma: Update on diagnosis and therapy.
Review in World journal of clinical cases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
37 citing papers in PubMed, 52 citations in OpenAlex.
- Primary hepatic angiosarcoma misdiagnosed as hemangioma despite repeated negative biopsies and sclerotherapy: A diagnostic pitfall.Radiology case reports · 2026Article
- Multifocal primary hepatic epithelioid hemangioendothelioma: a case in which tumor biopsy was critical to prevent misdiagnosis.Clinical journal of gastroenterology · 2026Article
- Characteristics of patients with epithelioid hemangioendothelioma (EHE): a retrospective analysis of the Charité- Universitätsmedizin Berlin.Journal of cancer research and clinical oncology · 2026Article
- A rare case of gastroduodenal junction Kaposiform hemangioendothelioma in a cat: pathological findings and follow-up.Veterinary research communications · 2026Article
- Disseminated hepatic epithelioid hemangioendothelioma with multiorgan metastases achieving long-term stability with Pazopanib: a case report.Frontiers in oncology · 2026Article
- Quantitative assessment of multi-phase contrast-enhanced CT features in hepatic epithelioid hemangioendothelioma.Journal of gastrointestinal oncology · 2025Article
- Hepatic epithelioid hemangioendothelioma managed with minimally invasive surgery: A case report.World journal of clinical cases · 2025Article
- Diagnostic and therapeutic understanding of multiple foci hepatic epithelioid haemangioendothelioma: A case report.Oncology letters · 2025Article
- Beyond cholangiocarcinoma: imaging features of mimicking pathologies in the biliary tract.Abdominal radiology (New York) · 2025Review
- Hepatic epithelioid hemangioendothelioma, a rare liver tumor: a case report and review of the literature.Frontiers in oncology · 2025Article
- A Rare Case of Solitary Primary and Recurrent Hepatic Epithelioid Hemangioendothelioma Undergoing Repeat Liver Resections.Surgical case reports · 2025Article
- Hepatic epithelioid hemangioendothelioma withFrontiers in oncology · 2025Article
- Case Report: A case of epithelioid hemangioendothelioma of the right femoral artery misdiagnosed as arterial occlusion.Frontiers in surgery · 2025Article
- Computed tomography and magnetic resonance imaging features of primary liver perivascular epithelioid cell tumor with renal angiomyolipoma: a case report and literature review.Frontiers in oncology · 2025Article
- The challenges of hepatic epithelioid hemangioendothelioma: the diagnosis and current treatments of a problematic tumor.Orphanet journal of rare diseases · 2024Review
- Hepatic epithelioid Hemangioendothelioma presenting synchronously with hepatocellular carcinoma-a case report.Oxford medical case reports · 2024Article
- Irreversible Electroporation as a Valid Treatment Option for Hepatic Epithelioid Hemangioendothelioma: An International Multicenter Experience.Cardiovascular and interventional radiology · 2024Article
- Hepatic Epithelioid Hemangioendothelioma in a Dog.Animals : an open access journal from MDPI · 2024Article
- A Young Female with a Hepatic Epithelioid Hemangioendothelioma.European journal of case reports in internal medicine · 2024Article
- Comprehensive evaluation of clinical outcomes in hepatic epithelioid hemangioendothelioma subsets: insights from SEER Database and departmental cohort analysis.Frontiers in immunology · 2024Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With an estimated incidence of only 1-2 cases in every 1 million people, hepatic epithelioid hemangioendothelioma (HEHE) is a rare vascular endothelial cell tumor occurring in the liver and consisting of epithelioid and histiocyte-like vascular endothelial cells in mucus or a fibrotic matrix. HEHE is characterized as a low-to-moderate grade malignant tumor and is classified into three types: solitary, multiple, and diffuse. Both the etiology and characteristic clinical manifestations of HEHE are unclear. However, HEHE has a characteristic appearance on imaging including ultrasound, magnetic resonance imaging, and positron emission tomography/computerized tomography. Still, its diagnosis depends mainly on pathological findings, with immunohistochemical detection of endothelial markers cluster of differentiation 31 (CD31), CD34, CD10, vimentin, and factor VIII antigen as the basis of diagnosis. Hepatectomy and/or liver transplantation are the first choice for treatment, but various chemotherapeutic drugs are reportedly effective, providing a promising treatment option. In this review, we summarize the literature related to the diagnosis and treatment of HEHE, which provides future perspectives for the clinical management of HEHE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.