Evidence map›Paper›PMID 33026497›Full record

Observational studyActa diabetologica2020

Lessons learned from the continuous glucose monitoring metrics in pediatric patients with type 1 diabetes under COVID-19 lockdown.

Avivit Brener, Kineret Mazor-Aronovitch, Marianna Rachmiel, Noa Levek, Galia Barash, Orit Pinhas-Hamiel, Yael Lebenthal, Zohar Landau

Open access · bronzeAbstract readObservational Study
In one paragraph

Observational study in Acta diabetologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 4 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 4 syntheses or guidelines pooled it, 65 citations in OpenAlex.

  1. Pooled it
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  5. Review
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  10. Endocrine manifestations of COVID-19 in children: A scoping review.Best practice & research. Clinical endocrinology & metabolism · 2023
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  13. Sustained Improvement in Glycemic Control in Emerging Adults with Type 1 Diabetes 2 Years After the Start of the COVID-19 Pandemic.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2023
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  17. Telemedicine for the Clinical Management of Diabetes; Implications and Considerations After COVID-19 Experience.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Avivit BrenerPediatric Endocrinology and Diabetes Unit, Dana Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 6423906, Tel Aviv, Israel. Avivit.brener@gmail.com.ORCID http://orcid.org/0000-0002-2742-8264
Kineret Mazor-AronovitchSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Marianna RachmielSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Noa LevekNational Juvenile Diabetes Center, Maccabi Health Care Services, Ra'anana, Israel.
Galia BarashSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Orit Pinhas-HamielSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Yael LebenthalPediatric Endocrinology and Diabetes Unit, Dana Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 6423906, Tel Aviv, Israel.
Zohar LandauNational Juvenile Diabetes Center, Maccabi Health Care Services, Ra'anana, Israel.
Tel Aviv University · ILBen-Gurion University of the Negev · ILMaccabi Healthcare Services · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsBillions of people have been under lockdown in an attempt to prevent COVID-19 spread. Lifestyle changes during lockdown could lead to deterioration of glycemic control in type 1 diabetes (T1D). We aimed to assess the impact of COVID-19 lockdown on the glycemic control of pediatric patients with T1D.

methodsThis observational real-life study from the AWeSoMe Group assessed continuous glucose monitoring (CGM) metrics of 102 T1D patients (52.9% males, mean age 11.2 ± 3.8 years, mean diabetes duration 4.2 ± 3.8 years) who used  Dexcom G5. The data were accessed without any interface between patients, caregivers, and the diabetes team. Study variables from CGM metrics were: mean glucose level, time-in-range (TIR, 70-180 mg/dL; 3.9-10 mmol/L), hypoglycemia (< 54 mg/dL; < 3 mmol/L), hyperglycemia (> 250 mg/dL; > 13.3 mmol/L), coefficient of variation (CV), and time CGM active before and during lockdown. Delta-variable = lockdown variable minus before-lockdown variable.

resultsThe mean TIR was 60.9 ± 14.3% before lockdown, with no significant change during lockdown (delta-TIR was 0.9 ± 7.9%). TIR during lockdown was significantly correlated with TIR before lockdown (r = 0.855, P < 0.001). Patients with improved TIR (delta-TIR > 3%) were significantly older than patients with stable or worse TIR (P = 0.028). Children aged < 10 years had a significantly higher CV before lockdown and during lockdown than children aged ≥ 10 years (P = 0.02 and P = 0.005, respectively). Among children aged < 10 years, a multiple linear regression model revealed associations of age and lower socioeconomic cluster with delta-TIR (F = 4.416, P = 0.019) and with delta-mean glucose (F = 4.459, P = 0.018).

conclusionsCGM metrics in pediatric patients with T1D were relatively stable during a nationwide lockdown. Intervention plans should focus on younger patients with lower socioeconomic position.

Indexed as

AdolescentBlood GlucoseBlood Glucose Self-MonitoringChildCoronavirus InfectionsCOVID-19Diabetes Mellitus, Type 1FemaleHumansLongitudinal StudiesMalePandemicsPneumonia, ViralBlood GlucoseAmbulatory glucose profileChildren and adolescentsContinuous glucose monitoring (CGM) metricsCOVID-19 lockdownType 1 diabetes

Identifiers

PMID33026497
PMCPMC7538839
OpenAlexW3092500584

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.