Evidence map›Paper›PMID 33028147›Full record

Trial reportJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2021

Cerebrovascular effects of glibenclamide investigated using high-resolution magnetic resonance imaging in healthy volunteers.

Mohammad Al-Mahdi Al-Karagholi, Hashmat Ghanizada, Cherie Amalie Waldorff Nielsen, Assan Ansari, Christian Gram, Samaria Younis, Mark B Vestergaard, Henrik Bw Larsson, Lene Theil Skovgaard, Faisal Mohammad Amin and 1 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. KFrontiers in neurology · 2024
    Pooled it
  3. The therapeutic pipeline in migraine: What does the future hold?Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Pharmacological Profiling of KPharmaceuticals (Basel, Switzerland) · 2023
    Article
  8. The ATP sensitive potassium channel (KFrontiers in molecular neuroscience · 2023
    Review
  9. Review
  10. Kir6.1 and SUR2B in Cantú syndrome.American journal of physiology. Cell physiology · 2022
    Review
  11. Review
  12. Review
  13. The Effect of KFrontiers in physiology · 2021
    Article
  14. The Ion Channel and GPCR Toolkit of Brain Capillary Pericytes.Frontiers in cellular neuroscience · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mohammad Al-Mahdi Al-KaragholiDepartment of Neurology, Faculty of Health and Medical Sciences, Danish Headache Center, University of Copenhagen, Rigshospitalet Glostrup, Denmark.ORCID 0000-0003-1118-9665
Hashmat GhanizadaDepartment of Neurology, Faculty of Health and Medical Sciences, Danish Headache Center, University of Copenhagen, Rigshospitalet Glostrup, Denmark.ORCID 0000-0001-7954-8519
Cherie Amalie Waldorff NielsenDepartment of Neurology, Faculty of Health and Medical Sciences, Danish Headache Center, University of Copenhagen, Rigshospitalet Glostrup, Denmark.
Assan AnsariDepartment of Neurology, Faculty of Health and Medical Sciences, Danish Headache Center, University of Copenhagen, Rigshospitalet Glostrup, Denmark.
Christian GramDepartment of Neurology, Faculty of Health and Medical Sciences, Danish Headache Center, University of Copenhagen, Rigshospitalet Glostrup, Denmark.
Samaria YounisDepartment of Neurology, Faculty of Health and Medical Sciences, Danish Headache Center, University of Copenhagen, Rigshospitalet Glostrup, Denmark.ORCID 0000-0002-9750-690X
Mark B VestergaardFunctional Imaging Unit, Faculty of Health and Medical Sciences, Department of Clinical Physiology, Nuclear Medicine and PET, University of Copenhagen, Rigshospitalet, Denmark.ORCID 0000-0002-3510-9204
Henrik Bw LarssonFunctional Imaging Unit, Faculty of Health and Medical Sciences, Department of Clinical Physiology, Nuclear Medicine and PET, University of Copenhagen, Rigshospitalet, Denmark.
Lene Theil SkovgaardDepartment of Biostatistics, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Faisal Mohammad AminDepartment of Neurology, Faculty of Health and Medical Sciences, Danish Headache Center, University of Copenhagen, Rigshospitalet Glostrup, Denmark.
Messoud AshinaDepartment of Neurology, Faculty of Health and Medical Sciences, Danish Headache Center, University of Copenhagen, Rigshospitalet Glostrup, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glibenclamide inhibits sulfonylurea receptor (SUR), which regulates several ion channels including SUR1-transient receptor potential melastatin 4 (SUR1-TRPM4) channel and ATP-sensitive potassium (K

Indexed as

AdultCerebral ArteriesCerebrovascular CirculationCromakalimCross-Over StudiesDouble-Blind MethodFemaleGlyburideHealthy VolunteersHumansKATP ChannelsMagnetic Resonance ImagingMaleYoung AdultCromakalimGlyburideKATP ChannelsHuman modelsKATP channellevcromakalimmigrainestroke

Identifiers

PMID33028147
PMCPMC8142144

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.