ArticleMolecular brain2020
Fear response-based prediction for stress susceptibility to PTSD-like phenotypes.
Article in Molecular brain, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Stress-Enhanced Fear Learning in Rodents: A Systematic Review and Meta-Analysis of Fear-Learning Sensitization After Severe Stress.Brain sciences · 2026Review
- Behavioral phenotype analysis highlights sleep heterogeneity and brain cellular activations in a mouse model of PTSD.Neurobiology of stress · 2026Article
- Interindividual and sex differences in resilience and vulnerability to post-traumatic stress disorder (PTSD): insights from animal models.Biology of sex differences · 2025Review
- ErbB4 precludes the occurrence of PTSD-like fear responses by supporting the bimodal activity of the central amygdala.Experimental & molecular medicine · 2024Article
- The amygdala NT3-TrkC pathway underlies inter-individual differences in fear extinction and related synaptic plasticity.Molecular psychiatry · 2024Article
- Witnessed trauma exposure induces fear in mice through a reduction in endogenous neurosteroid synthesis.Journal of neuroendocrinology · 2024Article
- Phosphodiesterase 7 inhibitor reduces stress-induced behavioral and cytoarchitectural changes in C57BL/6J mice by activating the BDNF/TrkB pathway.Frontiers in pharmacology · 2024Article
- Impact of stress resilience and susceptibility on fear learning, anxiety, and alcohol intake.Neurobiology of stress · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most individuals undergo traumatic stresses at some points in their life, but only a small proportion develop stress-related disorders such as anxiety diseases and posttraumatic stress disorder (PTSD). Although stress susceptibility is one determinant of mental disorders, the underlying mechanisms and functional implication remain unclear yet. We found that an increased amount of freezing that animals exhibited in the intertrial interval (ITI) of a stress-enhanced fear learning paradigm, predicts ensuing PTSD-like symptoms whereas resilient mice show ITI freezing comparable to that of unstressed mice. To examine the behavioral features, we developed a systematic analytical approach for ITI freezing and stress susceptibility. Thus, we provide a behavioral parameter for prognosis to stress susceptibility of individuals in the development of PTSD-like symptoms as well as a new mathematical means to scrutinize freezing behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.