Evidence map›Paper›PMID 33028568›Full record

ArticleBMJ case reports2020

Prolonged euglycemic diabetic ketoacidosis triggered by a single dose of sodium-glucose cotransporter 2 inhibitor.

Maki Miwa, Mikio Nakajima, Richard H Kaszynski, Hideaki Goto

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in BMJ case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Euglycemic Diabetic Ketoacidosis: Clinical Suspicion and Diagnosis.Clinical medicine insights. Endocrinology and diabetes · 2026
    Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Maki MiwaEmergency and Critical Care Center, Tokyo Metropolitan Hiroo Hospital, Shibuya-ku, Tokyo, Japan cucumber_cetriolo@nifty.com.ORCID http://orcid.org/0000-0002-7013-9863
Mikio NakajimaEmergency and Critical Care Center, Tokyo Metropolitan Hiroo Hospital, Shibuya-ku, Tokyo, Japan.
Richard H KaszynskiEmergency and Critical Care Center, Tokyo Metropolitan Hiroo Hospital, Shibuya-ku, Tokyo, Japan.
Hideaki GotoEmergency and Critical Care Center, Tokyo Metropolitan Hiroo Hospital, Shibuya-ku, Tokyo, Japan.
Tokyo Metropolitan Hiroo Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 45-year-old woman was admitted for diabetic ketoacidosis (DKA). Aggressive rehydration and continuous intravenous insulin resulted in improved blood glucose levels; however, metabolic acidosis persisted. One day prior to admission, the patient took a single dose of a sodium-glucose cotransporter 2 (SGLT2) inhibitor and this likely contributed to the prolonged euglycemic DKA. A single dose of this drug remained effective for over 100 hours as evidenced by massive excretion of urine glucose continuing long after blood glucose normalisation. SGLT2 inhibitor use should be refrained in cases in which DKA has already occurred as they may result in increasing severity or prolonged DKA.

Indexed as

AcidosisDiabetic KetoacidosisAdministration, IntravenousDiabetes Mellitus, Type 2Drug MonitoringDuration of TherapyFemaleFluid TherapyGlycemic ControlHumansHypoglycemic AgentsInsulinMiddle AgedSodium-Glucose Transporter 2 InhibitorsTreatment OutcomeHypoglycemic AgentsInsulinSodium-Glucose Transporter 2 Inhibitorsdiabetesdrugs: endocrine systemprimary care

Identifiers

PMID33028568
PMCPMC7542622
OpenAlexW3091903502

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.