Evidence map›Paper›PMID 33028824›Full record

ReviewSignal transduction and targeted therapy2020

NAD

Na Xie, Lu Zhang, Wei Gao, Canhua Huang, Peter Ernst Huber, Xiaobo Zhou, Changlong Li, Guobo Shen, Bingwen Zou

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Signal transduction and targeted therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06991712 (Comparisons of Nicotinamide Adenine Dinucleotide), which is not on this map. Cited by 588 papers.

0numbers the graph read from it
0cells of the map it votes in
588citing papers in PubMed
53.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06991712 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Comparisons of Nicotinamide Adenine Dinucleotide (NAD) Precursors for Neuroenhancement in Glaucoma Patients

TypeinterventionalSponsorChristopher Kai Shun LeungRan2025 to 2026Enrolled138ConditionsGlaucomaArmsNicotinamide Riboside, Nicotinamide, Nicotinamide Mononucleotide, Nicotinic Acid, Placebo (Corn Starch)
3 · Its place in the literature

Who cites it

588 citing papers in PubMed, 949 citations in OpenAlex.

  1. Trial
  2. Review
  3. Flavonoids fromJournal of enzyme inhibition and medicinal chemistry · 2026
    Article
  4. Article
  5. Microvascular Dysfunction and Redox Imbalance in Long COVID.Microcirculation (New York, N.Y. : 1994) · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Nicotinamide riboside enhances adoptive T cell therapy by promoting memory differentiation and metabolic fitness.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review

528 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Na Xie *State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, China.
Lu Zhang *State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, China.
Wei Gao *State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, China.
Canhua HuangState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, China.ORCID http://orcid.org/0000-0003-2247-7750
Peter Ernst HuberCCU Molecular and Radiation Oncology, German Cancer Research Center; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
Xiaobo ZhouFirst Department of Medicine, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Changlong LiWest China School of Basic Medical Sciences & Forensic Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China. changlongli@scu.edu.cn.
Guobo ShenState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, China. shenguobo@126.com.
Bingwen ZouState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, China. zoubingwen81@163.com.ORCID http://orcid.org/0000-0002-0825-3657
Sichuan University · CNGerman Cancer Research Center · DEHeidelberg University · DEWest China Medical Center of Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nicotinamide adenine dinucleotide (NAD

Indexed as

AgingCyclic ADP-RiboseHumansMetabolic DiseasesNADNADPNeoplasmsNeurodegenerative DiseasesOxidation-ReductionCyclic ADP-RiboseNAADPNADNADP

Identifiers

PMID33028824
PMCPMC7539288
OpenAlexW3092621787

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.