Evidence map›Paper›PMID 33029735›Full record

SynthesisNeuroradiology2021

Imaging endpoints of intracranial atherosclerosis using vessel wall MR imaging: a systematic review.

Jae W Song, Athanasios Pavlou, Morgan P Burke, Haochang Shou, Kofi-Buaku Atsina, Jiayu Xiao, Laurie A Loevner, David Mankoff, Zhaoyang Fan, Scott E Kasner

Abstract readSystematic Review
In one paragraph

Synthesis in Neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jae W SongDepartment of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA. jae.song@pennmedicine.upenn.edu.ORCID https://orcid.org/0000-0002-3127-6427
Athanasios PavlouDepartment of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.ORCID https://orcid.org/0000-0003-2105-318X
Morgan P BurkeDepartment of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.ORCID https://orcid.org/0000-0001-5422-0744
Haochang ShouDepartment of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.ORCID https://orcid.org/0000-0002-3043-047X
Kofi-Buaku AtsinaDepartment of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.ORCID https://orcid.org/0000-0002-1622-8478
Jiayu XiaoDepartment of Biomedical Sciences, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0001-7478-6534
Laurie A LoevnerDepartment of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.ORCID https://orcid.org/0000-0001-9004-0089
David MankoffDepartment of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.ORCID https://orcid.org/0000-0002-6971-5413
Zhaoyang FanDepartment of Biomedical Sciences, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-2693-0260
Scott E KasnerDepartment of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.ORCID https://orcid.org/0000-0003-0418-6917

Funding

Longitudinal and quantitative MR plaque imaging for prediction of response to medical management in symptomatic intracranial atherosclerosisR01HL147355 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FAN, ZHAOYANG · 2019 to 2023
$2.1M
NHLBI NIH HHS R01 HL147355NHLBI NIH HHS R01HL147355NINDS NIH HHS L30 NS118632RSNA Research and Education Foundation RSCH1929
6 · The paper itself

Abstract

purposeThe vessel wall MR imaging (VWI) literature was systematically reviewed to assess the criteria and measurement methods of VWI-related imaging endpoints for symptomatic intracranial plaque in patients with ischemic events.

methodsPubMed, Scopus, Web of Science, EMBASE, and Cochrane databases were searched up to October 2019. Two independent reviewers extracted data from 47 studies. A modified Guideline for Reporting Reliability and Agreement Studies was used to assess completeness of reporting.

resultsThe specific VWI-pulse sequence used to identify plaque was reported in 51% of studies. A VWI-based criterion to define plaque was reported in 38% of studies. A definition for culprit plaque was reported in 40% of studies. Frequently scored qualitative imaging endpoints were plaque quadrant (21%) and enhancement (21%). Frequently measured quantitative imaging endpoints were stenosis (19%), lumen area (15%), and remodeling index (14%). Reproducibility for all endpoints ranged from good to excellent (range: ICC

conclusionsInvestigators are using different criteria to identify and measure VWI-imaging endpoints for culprit intracranial plaque. Early awareness of these differences to address methods of acquisition and measurement will help focus research resources and efforts in technique optimization and measurement reproducibility. Consensual definitions to detect plaque will be important to develop automatic lesion detection tools particularly in the era of radiomics.

Indexed as

Intracranial ArteriosclerosisPlaque, AtheroscleroticHumansMagnetic Resonance AngiographyMagnetic Resonance ImagingReproducibility of ResultsAtherosclerosisReproducibility, biomarkerVessel wall MR imaging

Identifiers

PMID33029735
PMCPMC8024415

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.