Evidence map›Paper›PMID 33030307›Full record

ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2020

Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop.

Berislav V Zlokovic, Rebecca F Gottesman, Kenneth E Bernstein, Sudha Seshadri, Ann McKee, Heather Snyder, Steven M Greenberg, Kristine Yaffe, Chris B Schaffer, Chun Yuan and 15 more

3 registry-linked trialsOpen access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT05565976. Cited by 145 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
145citing papers in PubMed, 3 pooled it
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05565976 phase2 / phase3unknown status

Dapagliflozin Effect in Cognitive Impairment in Stroke Trial

Ran2020Enrolled270Registered outcomes3Posted comparisons0ConditionsDementia, Vascular, Metabolic Syndrome, Mild Cognitive Impairment, Stroke, IschemicArmsAntidiabetic, Dapagliflozin 10mg Tab, Platelet Antiaggregant, Statins (Cardiovascular Agents)
PMID 29016744PMID 29446769PMID 32559474PMID 32352644PMID 32317958PMID 32178931PMID 32144994PMID 32115470PMID 31535829PMID 31248555PMID 31236801PMID 29371333other papers from this trial
Open the trial in the graph
NCT06459349 nacompletednot on this mapstarted 2024, after this paper: background citation

Effects of Exteroceptive and Proprioceptive Sensory Stimulation Versus Sensorimotor Therapy on Spasticity, Motor Function and Activities of Daily Living in Patients With Stroke

TypeinterventionalSponsorRiphah International UniversityRan2024 to 2024Enrolled42ConditionsStroke, Ischemic, Proprioceptive Disorders, Sensory DefectArmsexteroceptive and proprioceptive sensory stimulation training, sensorimotor therapy group
NCT06836141 recruitingnot on this mapstarted 2025, after this paper: background citation

Silent Brain Infarcts in Spontaneous Intracerebral Hemorrhage as a Prognostic Biomarker for Vascular Contributions to Cognitive Impairment and Dementia (VCID)

Typeobservational_patient_registrySponsorRush University Medical CenterRan2025 to 2029Enrolled118ConditionsPrimary Intracerebral HemorrhageArmsMRI, Blood Draw, Cognitive Test
3 · Its place in the literature

Who cites it

145 citing papers in PubMed, 3 syntheses or guidelines pooled it, 216 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Review
  7. Article
  8. Cognitive reserve against vascular contributions to cognitive impairment and dementia: A scoping review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  9. Article
  10. Review
  11. Article
  12. Vascular contribution to cognitive impairment and dementia (VCID): proceedings of 2025 workshop of the Jackson Laboratory.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review

85 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 19 institutions in 3 countries.

Berislav V ZlokovicUniversity of Southern California, Los Angeles, California, USA.
Rebecca F GottesmanJohns Hopkins University, Baltimore, Maryland, USA.
Kenneth E BernsteinCedars-Sinai Medical Center, Los Angeles, California, USA.
Sudha SeshadriUniversity of Texas Health Science Center, San Antonio and Boston University, San Antonio, Texas, USA.
Ann McKeeVA Boston Healthcare System and Boston University, Boston, Massachusetts, USA.
Heather SnyderAlzheimer's Association, Chicago, Illinois, USA.
Steven M GreenbergMassachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Kristine YaffeUniversity of California, San Francisco, San Francisco, California, USA.
Chris B SchafferCornell University, Ithaca, New York, USA.
Chun YuanUniversity of Washington, Seattle, Washington, USA.
Timothy M HughesWake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Mat J DaemenAmsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Jeff D WilliamsonWake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Hector M GonzálezUniversity of California San Diego, La Jolla, California, USA.
Julie SchneiderRush University, Chicago, Illinois, USA.
Cheryl L WellingtonUniversity of British Columbia, Vancouver and Kelowna, British Columbia.
Zvonimir S KatusicMayo Clinic, Rochester, Minnesota, USA.
Luke StoeckelNational Institute on Aging, Bethesda, Maryland, USA.
James I KoenigNational Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.
Roderick A CorriveauNational Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.
Lawrence FineNational Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
Zorina S GalisNational Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
Jared ReisNational Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
Jacqueline D WrightNational Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
Jue ChenNational Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
National Heart Lung and Blood Institute · USNational Institute of Neurological Disorders and Stroke · USWake Forest University · USAlzheimer's Association · USBoston University · USCedars-Sinai Medical Center · USCornell University · USJohns Hopkins University · USKelowna General Hospital · CAMassachusetts General Hospital · USMayo Clinic · USNational Institute on Aging · USRush University · USThe University of Texas Health Science Center at San Antonio · USUniversity of Amsterdam · NLUniversity of California San Diego · USUniversity of California, San Francisco · USUniversity of Southern California · USUniversity of Washington · US

Funding

NIA NIH HHS P30 AG049638
6 · The paper itself

Abstract

Vascular contributions to cognitive impairment and dementia (VCID) are characterized by the aging neurovascular unit being confronted with and failing to cope with biological insults due to systemic and cerebral vascular disease, proteinopathy including Alzheimer's biology, metabolic disease, or immune response, resulting in cognitive decline. This report summarizes the discussion and recommendations from a working group convened by the National Heart, Lung, and Blood Institute and the National Institute of Neurological Disorders and Stroke to evaluate the state of the field in VCID research, identify research priorities, and foster collaborations. As discussed in this report, advances in understanding the biological mechanisms of VCID across the wide spectrum of pathologies, chronic systemic comorbidities, and other risk factors may lead to potential prevention and new treatment strategies to decrease the burden of dementia. Better understanding of the social determinants of health that affect risks for both vascular disease and VCID could provide insight into strategies to reduce racial and ethnic disparities in VCID.

Indexed as

EducationAgingBiomarkersBrainCerebrovascular DisordersCognitive DysfunctionDementia, VascularHumansNational Heart, Lung, and Blood Institute (U.S.)National Institute of Neurological Disorders and Stroke (U.S.)United StatesBiomarkersAlzheimer's disease-related dementiascerebrovascular and cardiovascular diseasevascular contributions to cognitive impairment and dementia

Identifiers

PMID33030307
OpenAlexW3091838285

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.