Evidence map›Paper›PMID 33030428›Full record

ArticleeLife2020

Cadherin preserves cohesion across involuting tissues during

Kristopher M Barnes, Li Fan, Mark W Moyle, Christopher A Brittin, Yichi Xu, Daniel A Colón-Ramos, Anthony Santella, Zhirong Bao

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. An analysis of contractile and protrusive cell behaviors at the superficial surface of the zebrafish neural plate.Developmental dynamics : an official publication of the American Association of Anatomists · 2025
    Article
  3. Nervous system-wide analysis of allScience advances · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Delineating the mechanisms and design principles ofComputational and structural biotechnology journal · 2022
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Kristopher M BarnesDevelopmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, United States.ORCID 0000-0003-2546-9529
Li FanDevelopmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, United States.ORCID 0000-0003-1780-6919
Mark W MoyleDepartment of Neuroscience and Department of Cell Biology, Yale University School of Medicine, New Haven, United States.
Christopher A BrittinDevelopmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, United States.ORCID 0000-0002-1143-554X
Yichi XuDevelopmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, United States.
Daniel A Colón-RamosDepartment of Neuroscience and Department of Cell Biology, Yale University School of Medicine, New Haven, United States.ORCID 0000-0003-0223-7717
Anthony SantellaDevelopmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, United States.
Zhirong BaoDevelopmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, United States.ORCID 0000-0002-2201-2745
Memorial Sloan Kettering Cancer Center · USUniversity of Puerto Rico, Medical Sciences Campus · PRYale University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
WormGUIDES: A Resource for Global Understanding in Dynamic Embryonic SystemsR24OD016474 · OD · YALE UNIVERSITY · PI BAO, ZHIRONG, COLON-RAMOS, DANIEL A · 2013 to 2020
$6.5M
Cellular and molecular mechanisms that temporally and spatially restrict synapticR01NS076558 · NINDS · YALE UNIVERSITY · PI COLON-RAMOS, DANIEL A · 2012 to 2022
$4.1M
The Ubiquitin-Proteasome System in Metazoan EmbryogenesisR01GM097576 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI BAO, ZHIRONG · 2011 to 2020
$3.3M
Molecular and cellular mechanisms required for fascicle organization during neurodevelopmentF32NS098616 · NINDS · YALE UNIVERSITY · PI MOYLE, MARK WAYNE · 2016 to 2018
$192k
Chan Zuckerberg Initiative 2019-198110 (5022)Howard Hughes Medical InstituteNCI NIH HHS P30 CA008748NIGMS NIH HHS R01 GM097576NIH HHS P40 OD010440NIH HHS R24 OD016474NINDS NIH HHS F32 NS098616NINDS NIH HHS R01 NS076558
6 · The paper itself

Abstract

The internalization of the central nervous system, termed neurulation in vertebrates, is a critical step in embryogenesis. Open questions remain regarding how force propels coordinated tissue movement during the process, and little is known as to how internalization happens in invertebrates. We show that in

Indexed as

NeurulationAnimalsCadherinsCaenorhabditis elegansCaenorhabditis elegans ProteinsEmbryo, NonmammalianMorphogenesisNeural PlatePharynxCadherinsCaenorhabditis elegans Proteinshmr-1 protein, C elegansC. eleganscollective tissue movementevolution of the brainforce transmissionHMR-1/CadherinmorphogenesisneurosciencePharynx

Identifiers

PMID33030428
PMCPMC7544503
OpenAlexW3092042678

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.