Evidence map›Paper›PMID 33031923›Full record

ArticleBioorganic & medicinal chemistry letters2020

Structure activity relationship of novel antiviral nucleosides against Enterovirus A71.

Dilip K Tosh, Kiran S Toti, Brett L Hurst, Justin G Julander, Kenneth A Jacobson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Structure activity relationships of 5-HTEuropean journal of medicinal chemistry · 2023
    Article
  4. Enterovirus A71 antivirals: Past, present, and future.Acta pharmaceutica Sinica. B · 2022
    Article
  5. Review
  6. Isolation and Identification ofFrontiers in pharmacology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dilip K ToshLaboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, 9000 Rockville Pike, Bethesda, MA 20892, USA.
Kiran S TotiLaboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, 9000 Rockville Pike, Bethesda, MA 20892, USA.
Brett L HurstInstitute for Antiviral Research, Utah State University, 5600 Old Main Hill, VSB 305, Logan, UT 84322-5600, USA.
Justin G JulanderInstitute for Antiviral Research, Utah State University, 5600 Old Main Hill, VSB 305, Logan, UT 84322-5600, USA.
Kenneth A JacobsonLaboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, 9000 Rockville Pike, Bethesda, MA 20892, USA. Electronic address: kennethj@niddk.nih.gov.

Funding

Development Of Drugs Acting At Adenosine ReceptorsZIADK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$10.4M
Task B6: In Vitro Assessment for Antimicrobial Activity Against Respiratory Viruses, Including SARS-CoV-275N93019D00021 · NIAID · UTAH STATE UNIVERSITY · PI JULANDER, JUSTIN · 2019 to 2025
$7.3M
CLINICAL CENTRAL LABORATORY SERVICES TO SUPPORT COVID-19 VACCINE STUDIES75N93021D00021 · NIAID · PI BEECH, TIFFANI · 2021 to 2023
$1.6M
Intramural NIH HHS ZIA DK031117NIAID NIH HHS 75N93019D00021NIAID NIH HHS 75N93021D00021NIMH NIH HHS HHSN271200800025C
6 · The paper itself

Abstract

Various (North)-methanocarba adenosine derivatives, containing rigid bicyclo[3.1.0]hexane ribose substitution, were screened for activity against representative viruses, and inhibition was observed after treatment of Enterovirus A71 with a 2-chloro-N

Indexed as

AdenosineAnimalsAntiviral AgentsBridged Bicyclo CompoundsCell Line, TumorChlorocebus aethiopsEnterovirus A, HumanHumansMicrobial Sensitivity TestsMolecular StructureSmall Molecule LibrariesStructure-Activity RelationshipVero CellsAdenosineAntiviral AgentsBridged Bicyclo CompoundsSmall Molecule LibrariesAdenosine analogueAntiviralEnterovirusMethanocarbaNucleosideStructure activity relationship

Identifiers

PMID33031923
PMCPMC7534897

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.