ArticleScientific reports2020
Modeling the potential of wAu-Wolbachia strain invasion in mosquitoes to control Aedes-borne arboviral infections.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of Mathematical Models of Dengue Transmission and Vector Control: 2010-2020.Viruses · 2023Pooled it
- An eco-epidemiological model for malaria withModeling earth systems and environment · 2025Article
- Wolbachia confers protection against the entomopathogenic fungus Metarhizium pingshaense in African Aedes aegypti.Environmental microbiology reports · 2024Article
- Mitigating dengue transmission in Africa: the need forFrontiers in public health · 2024Article
- Quantifying the impact of Wolbachia releases on dengue infection in Townsville, Australia.Scientific reports · 2023Article
- Modelling the ecological dynamics of mosquito populations with multiple co-circulating Wolbachia strains.Scientific reports · 2022Article
- Wolbachia inhibits ovarian formation and increases blood feeding rate in female Aedes aegypti.PLoS neglected tropical diseases · 2022Article
- ARBO: Arbovirus modeling and uncertainty quantification toolbox.Software impacts · 2022Article
- RNA virome diversity andThe Journal of general virology · 2021Article
- A Review:Vaccines · 2021Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arboviral infections such as dengue, Zika and chikungunya are fast spreading diseases that pose significant health problems globally. In order to control these infections, an intracellular bacterium called Wolbachia has been introduced into wild-type mosquito populations in the hopes of replacing the vector transmitting agent, Aedes aegypti with one that is incapable of transmission. In this study, we developed a Wolbachia transmission model for the novel wAu strain which possesses several favourable traits (e.g., enhanced viral blockage and maintenance at higher temperature) but not cyctoplasmic incompatibility (CI)-when a Wolbachia-infected male mosquito mates with an uninfected female mosquito, producing no viable offspring. This model describes the competitive dynamics between wAu-Wolbachia-infected and uninfected mosquitoes and the role of imperfect maternal transmission. By analysing the system via computing the basic reproduction number(s) and stability properties, the potential of the wAu strain as a viable strategy to control arboviral infections is established. The results of this work show that enhanced maintenance of Wolbachia infection at higher temperatures can overcome the lack of CI induction to support wAu-Wolbachia infected mosquito invasion. This study will support future arboviral control programs, that rely on the introduction of new Wolbachia variants.
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