Evidence map›Paper›PMID 33035052›Full record

ArticleACS chemical biology2020

Halogenation-Dependent Effects of the Chlorosulfolipids of

Frank R Moss Iii, Gabrielle E Cabrera, Grace M McKenna, Giulio J Salerno, Steven R Shuken, Matthew L Landry, Thomas M Weiss, Noah Z Burns, Steven G Boxer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Frank R Moss IiiDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.ORCID 0000-0002-6149-6447
Gabrielle E CabreraDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Grace M McKennaDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Giulio J SalernoDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Steven R ShukenDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Matthew L LandryDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Thomas M WeissStanford Synchrotron Radiation Laboratory, Stanford Linear Accelerator Center, Stanford University, Menlo Park, California 94025, United States.
Noah Z BurnsDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.ORCID 0000-0003-1064-4507
Steven G BoxerDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.ORCID 0000-0001-9167-4286
Stanford University · USSLAC National Accelerator Laboratory · US

Funding

X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6M
Biophysical Studies of Macromolecules and Molecular AssembliesR35GM118044 · NIGMS · STANFORD UNIVERSITY · PI STEVEN G. BOXER · 2016 to 2026
$7.2M
PILATUS3 X 1M X-ray detectorS10OD021512 · OD · STANFORD UNIVERSITY · PI WEIS, WILLIAM I · 2016 to 2016
$550k
NIGMS NIH HHS P41 GM103393NIGMS NIH HHS R35 GM118044NIH HHS S10 OD021512
6 · The paper itself

Abstract

The chlorosulfolipids are amphiphilic natural products with stereochemically complex patterns of chlorination and sulfation. Despite their role in toxic shellfish poisoning, potential pharmacological activities, and unknown biological roles, they remain understudied due to the difficulties in purifying them from natural sources. The structure of these molecules, with a charged sulfate group in the middle of the hydrophobic chain, appears incompatible with the conventional lipid bilayer structure. Questions about chlorosulfolipids remain unanswered partly due to the unavailability of structural analogues with which to conduct structure-function studies. We approach this problem by combining enantioselective total synthesis and membrane biophysics. Using a combination of Langmuir pressure-area isotherms of lipid monolayers, fluorescence imaging of vesicles, mass spectrometry imaging, natural product isolation, small-angle X-ray scattering, and cryogenic electron microscopy, we show that danicalipin A (

Indexed as

HalogenationLipid BilayersLipidsMembrane FluidityOchromonasPhase Transitiondanicalipin ALipid BilayersLipids

Identifiers

PMID33035052
PMCPMC8557392
OpenAlexW3092246638

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.