Evidence map›Paper›PMID 33035680›Full record

ArticleBiochimica et biophysica acta. Molecular and cell biology of lipids2021

Lysophosphatidic acid receptors 2 and 3 regulate erythropoiesis at different hematopoietic stages.

Jui-Chung Chiang, Wei-Min Chen, Kuan-Hung Lin, Kai Hsia, Ya-Hsuan Ho, Yueh-Chien Lin, Tang-Long Shen, Jen-Her Lu, Shih-Kuo Chen, Chao-Ling Yao and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta. Molecular and cell biology of lipids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. LPAInternational journal of molecular sciences · 2024
    Article
  5. Article
  6. Article
  7. Revisiting the role of lysophosphatidic acid in stem cell biology.Experimental biology and medicine (Maywood, N.J.) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Jui-Chung ChiangDepartment of Life Science, National Taiwan University, Taipei, Taiwan; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Wei-Min ChenDepartment of Life Science, National Taiwan University, Taipei, Taiwan; Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Kuan-Hung LinDepartment of Life Science, National Taiwan University, Taipei, Taiwan.
Kai HsiaDepartment of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan.
Ya-Hsuan HoWellcome Trust-Medical Research Council Cambridge Stem Cell Institute and Department of Haematology, University of Cambridge, Cambridge, United Kingdom.
Yueh-Chien LinDepartment of Life Science, National Taiwan University, Taipei, Taiwan.
Tang-Long ShenDepartment of Plant Pathology and Microbiology, National Taiwan University, Taipei, Taiwan; Center for Biotechnology, National Taiwan University, Taipei, Taiwan.
Jen-Her LuDepartment of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Surgery, Medicine & Pediatrics, School of Medicine, National Defense Medical Center, Taipei, Taiwan; Department of Pediatrics, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Shih-Kuo ChenDepartment of Life Science, National Taiwan University, Taipei, Taiwan; Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei, Taiwan.
Chao-Ling YaoDepartment of Chemical Engineering and Materials Science, Yuan Ze University, Taoyuan, Taiwan.
Benjamin P C ChenDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: Benjamin.chen@utsouthwestern.edu.
Hsinyu LeeDepartment of Life Science, National Taiwan University, Taipei, Taiwan; Center for Biotechnology, National Taiwan University, Taipei, Taiwan; Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan; Angiogenesis Research Center, National Taiwan University, Taipei, Taiwan; Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan. Electronic address: hsinyu@ntu.edu.tw.
National Taiwan University · TWThe University of Texas Southwestern Medical Center · USMedical Research Council · GBNational Yang Ming Chiao Tung University · TWTaipei Veterans General Hospital · TWYuan Ze University · TW

Funding

DNA-PKcs and PIDD interaction in DNA damage responseR01CA233594 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI DAVIS, ANTHONY J · 2019 to 2023
$1.8M
NCI NIH HHS R01 CA233594
6 · The paper itself

Abstract

Hematopoiesis, the complex developmental process that forms blood components and replenishes the blood system, involves multiple intracellular and extracellular mechanisms. We previously demonstrated that lysophosphatidic acid (LPA), a lipid growth factor, has opposing regulatory effects on erythrocyte differentiation through activation of LPA receptors 2 and 3; yet the mechanisms underlying this process remain unclear. In this study, LPA

Indexed as

Anemia, HemolyticAnimalsCell DifferentiationCell LineageDisease Models, AnimalErythroid CellsErythropoiesisGene Expression RegulationHumansIsoquinolinesK562 CellsLysophospholipidsMaleMiceMice, Inbred BALB CMyeloid Cells1-oleoyl-2-O-methyl-rac-glycerophosphothionateIsoquinolinesLpar3 protein, mouselysophosphatidic acidLysophospholipidsOrganothiophosphatesphenylhydrazinePhenylhydrazinesPhosphatidic AcidsReceptors, Lysophosphatidic Acid1-Oleoyl-2-O-methyl-rac-glycerophosphothionateAnemiaErythropoiesisGRI compound 977143Lysophosphatidic acidLysophosphatidic acid receptor

Identifiers

PMID33035680
PMCPMC7683362
OpenAlexW3091917949

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.