Evidence map›Paper›PMID 33036331›Full record

ArticleJournal of clinical medicine2020

CDK 4/6 Inhibition Overcomes Acquired and Inherent Resistance to PI3Kα Inhibition in Pre-Clinical Models of Head and Neck Squamous Cell Carcinoma.

Eric Remer, Mai Badarni, Elad Hikri, Avraham Dayan, Lirit Levi, Aron Popovtzer, Muhammed Iraqi, Angel Porgador, Ben-Zion Joshua, Gideon Bachar and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Comparative Functional Effects of Abemaciclib and Arcyriaflavin A inInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Organoids and Liquid Biopsy in Oral Cancer Research.Journal of clinical medicine · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Eric RemerDepartment of Otolaryngology-Head and Neck Surgery, Meir Medical Center, Kfar Saba 4428164, Israel.
Mai BadarniThe Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
Elad HikriSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
Avraham DayanSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
Lirit LeviSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
Aron PopovtzerSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
Muhammed IraqiThe Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
Angel PorgadorThe Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
Ben-Zion JoshuaDepartment of Otolaryngology-Head and Neck Surgery, Soroka University Medical Center, Beer-Sheva 84011, Israel.
Gideon BacharSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
Moshe ElkabetsThe Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
Maurizio ScaltritiHuman Oncology & Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Aviram MizrachiSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
Tel Aviv University · ILBen-Gurion University of the Negev · ILMemorial Sloan Kettering Cancer Center · USSoroka Medical Center · IL

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Israel Science Foundation #700/16NCI NIH HHS P30 CA008748United States-Israel Binational Science Foundation #2017323
6 · The paper itself

Abstract

Activating alterations in

Indexed as

CDK 4/6head and neck squamous cell carcinomahuman papillomavirusmTORPI3KPIK3CA

Identifiers

PMID33036331
PMCPMC7601167
OpenAlexW3092401347

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.