Evidence map›Paper›PMID 33040605›Full record

ReviewFuture medicinal chemistry2020

Neurochemical regulators of food behavior for pharmacological treatment of obesity: current status and future prospects.

Gayane Sargis Vardanyan, Hasmik Samvel Harutyunyan, Michail Iosif Aghajanov, Ruben Sargis Vardanyan

Abstract readReview
In one paragraph

Review in Future medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gayane Sargis VardanyanDepartment of Biochemistry, Yerevan State Medical University, 2 Koryun str., Yerevan, 0025, Armenia.ORCID 0000-0003-2640-1809
Hasmik Samvel HarutyunyanDepartment of Biochemistry, Yerevan State Medical University, 2 Koryun str., Yerevan, 0025, Armenia.ORCID 0000-0002-4753-4857
Michail Iosif AghajanovDepartment of Biochemistry, Yerevan State Medical University, 2 Koryun str., Yerevan, 0025, Armenia.ORCID 0000-0001-9459-8557
Ruben Sargis VardanyanDepartment of Chemistry & Biochemistry, University of Arizona, 1306 East University Boulevard, PO Box 210041, Tucson, AZ 85721, USA.ORCID 0000-0001-6222-7786

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent decades, obesity has become a pandemic disease and appears to be an ultimate medical and social problem. Existing antiobesity drugs show low efficiency and a wide variety of side effects. In this review, we discuss possible mechanisms underlying brain-gut-adipose tissue axis, as well as molecular biochemical characteristics of various neurochemical regulators of body weight and appetite. Multiple brain regions are responsible for eating behavior, hedonic eating and food addiction. The existing pharmacological targets for treatment of obesity were reviewed as well.

Indexed as

Adipose TissueAnimalsAnti-Obesity AgentsBody WeightBrainFeeding BehaviorGastrointestinal MicrobiomeHumansObesityTranscription FactorsAnti-Obesity AgentsTranscription Factorsanti-obesity drugshypothalamusneurochemical regulatorsobesity

Identifiers

PMID33040605
PMCPMC7592841

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.