Evidence mapPaperPMID 33042004Full record

Trial reportFrontiers in endocrinology2020

Efficacy of a 2-Month Very Low-Calorie Ketogenic Diet (VLCKD) Compared to a Standard Low-Calorie Diet in Reducing Visceral and Liver Fat Accumulation in Patients With Obesity.

Guilherme Moura Cunha, German Guzman, Livia Lugarinho Correa De Mello, Barbara Trein, Luciana Spina, Isabela Bussade, Juliana Marques Prata, Ignacio Sajoux, Walmir Countinho

Registry-linked trialOpen access · goldAbstract readComparative StudyRandomized Controlled Trial
In one paragraph

Trial report in Frontiers in endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05275608 (Effects of Very Low Calorie Ketogenic Diet on Microbiota, Adipose Tissue and Immunitary Regulation), which is not on this map. Cited by 78 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 6 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05275608 narecruitingnot on this mapstarted 2022, after this paper: background citation

Effects of Very Low Calorie Ketogenic Diet on Microbiota, Adipose Tissue and Immunitary Regulation: Pilot Study on Patients with Metabolic Syndrome

TypeinterventionalSponsorAzienda Ospedaliero Universitaria Maggiore della CaritaRan2022 to 2025Enrolled40ConditionsDiabetes Mellitus, Type 2, Non-alcoholic Fatty Liver Disease, Obesity, Metabolic SyndromeArmsVLCKD diet with replacing meals, Hypocaloric mediterranean Diet
3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 6 syntheses or guidelines pooled it, 132 citations in OpenAlex.

  1. Pooled it
  2. Guideline
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  4. Pooled it
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  7. Trial
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  9. Article
  10. Multidisciplinary Therapy to Target Obesity and Its Complications in Adult Population: A Narrative Review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Review
  11. Article
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  20. Review

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Guilherme Moura CunhaDepartment of Radiology, University of California, San Diego, La Jolla, CA, United States.
German GuzmanPronokal Group, Barcelona, Spain.
Livia Lugarinho Correa De MelloInstituto Estadual de Diabetes e Endocrinologia Luiz Capriglione, Rio de Janeiro, Brazil.
Barbara TreinInstituto Estadual de Diabetes e Endocrinologia Luiz Capriglione, Rio de Janeiro, Brazil.
Luciana SpinaRio de Janeiro, Rio de Janeiro, Brazil.
Isabela BussadeClínica Isabela Bussade, Rio de Janeiro, Brazil.
Juliana Marques PrataClinical Diagnostic Imaging (CDPI), Rio de Janeiro, Brazil.
Ignacio SajouxPronokal Group, Barcelona, Spain.
Walmir CountinhoInstituto Estadual de Diabetes e Endocrinologia Luiz Capriglione, Rio de Janeiro, Brazil.
Instituto Estadual de Diabetes e Endocrinologia Luiz Capriglione · BRFundación Pronokal · ESUniversity of California, San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adipose TissueAdolescentAdultCaloric RestrictionDiet, KetogenicFatty LiverFemaleHumansIntra-Abdominal FatLiverMaleMiddle AgedObesityPilot ProjectsProspective StudiesTreatment Outcomeketogenic dietliver PDFFNAFLDPnk methodvery low-calorie ketogenic dietvisceral adipose tissue

Identifiers

PMID33042004
PMCPMC7521128
OpenAlexW3086284445

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.