Evidence map›Paper›PMID 33044717›Full record

ArticleThe international journal of cardiovascular imaging2021

Clinical implication of QFR in patients with ST-segment elevation myocardial infarction after drug-eluting stent implantation.

Jiani Tang, Jiapeng Chu, Hanjing Hou, Yan Lai, Shengxian Tu, Fei Chen, Yian Yao, Zi Ye, Yanhua Gao, Yu Mao and 2 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in The international journal of cardiovascular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.

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  9. Impact of morphofunctional assessment with quantitative flow ratio and optical coherence tomography in patients with acute coronary syndromes.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Jiani Tang *Department of Cardiology, Tongji Hospital, Tongji University, No. 389, Xincun Rd, Putuo District, Shanghai, 200065, China.
Jiapeng Chu *Department of Cardiology, Tongji Hospital, Tongji University, No. 389, Xincun Rd, Putuo District, Shanghai, 200065, China.
Hanjing HouDepartment of Cardiology, Seventh People's Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yan LaiDepartment of Cardiology, Tongji Hospital, Tongji University, No. 389, Xincun Rd, Putuo District, Shanghai, 200065, China.
Shengxian TuBiomedical Instrument Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Fei ChenDepartment of Cardiology, Tongji Hospital, Tongji University, No. 389, Xincun Rd, Putuo District, Shanghai, 200065, China.
Yian YaoDepartment of Cardiology, Tongji Hospital, Tongji University, No. 389, Xincun Rd, Putuo District, Shanghai, 200065, China.
Zi YeDepartment of Cardiology, Tongji Hospital, Tongji University, No. 389, Xincun Rd, Putuo District, Shanghai, 200065, China.
Yanhua GaoDepartment of Cardiology, Tongji Hospital, Tongji University, No. 389, Xincun Rd, Putuo District, Shanghai, 200065, China.
Yu MaoDepartment of Cardiology, Tongji Hospital, Tongji University, No. 389, Xincun Rd, Putuo District, Shanghai, 200065, China.
Shaowei ZhuangDepartment of Cardiology, Seventh People's Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xuebo LiuDepartment of Cardiology, Tongji Hospital, Tongji University, No. 389, Xincun Rd, Putuo District, Shanghai, 200065, China. liuxuebo70@126.com.ORCID http://orcid.org/0000-0001-9985-8960
Tongji University · CNShanghai University of Traditional Chinese Medicine · CNShanghai Jiao Tong University · CN

Funding

Grant of Shanghai Science and Technology Committee 18411950300Grant of Shanghai Science and Technology Committee 19411963200Grant of Shanghai Science and Technology Committee 19XD1403300National Natural Science Foundation of China 81670403Shanghai Municipal Health Commission 2019LJ10
6 · The paper itself

Abstract

The feasibility and prognostic value of quantitative flow ratio (QFR) after percutaneous coronary intervention (PCI) in ST-segment elevation myocardial infarction (STEMI) patients have not been assessed. The aim of this study was to investigate the prognostic utility of post-PCI QFR to predict outcomes in STEMI and determine the influence of functional results, in both culprit and nonculprit lesions, after PCI. Patients undergoing PCI of culprit lesions and receiving staged procedures of nonculprit lesions after 7 days were enrolled from 2 centers and underwent post-PCI QFR. The primary outcome was the vessel-oriented composite endpoints (VOCEs), defined as vessel-related cardiovascular death, vessel-related myocardial infarction, and target vessel revascularization. Four hundred fifteen vessels (186 culprit lesions and 219 nonculprit lesions) in 186 patients were analyzed. Measured at staged PCI, the post-PCI QFR of culprit lesions was significantly lower than that of nonculprit lesions (0.92 ± 0.10 versus 0.95 ± 0.08, p < 0.001). The multivariable model demonstrated that low post-PCI QFR was an independent predictor of 2-year VOCE (20.8% versus 5.7%; hazard ratio 2.718; 95% CI 1.347-5.486; p = 0.005). In STEMI patients with a low angiography-derived index of microcirculatory resistance (≤ 40U), a good correlation and agreement between post-PCI QFR value of culprit lesions at primary and staged procedures (r = 0.942; mean difference: - 0.0017 [- 0.074 to 0.070]) was identified. In conclusion, culprit lesions suffered from suboptimal functional results more frequently compared to nonculprit lesions after PCI in STEMI patients. Low post-PCI QFR was associated with subsequent adverse clinical outcomes. After stenting, culprit lesions may feasibly be assessed through QFR without significant microvascular dysfunction.

Indexed as

Coronary AngiographyDrug-Eluting StentsFractional Flow Reserve, MyocardialAgedBlood Flow VelocityChinaCoronary VesselsDatabases, FactualFeasibility StudiesFemaleHumansMaleMicrocirculationMiddle AgedPercutaneous Coronary InterventionPredictive Value of TestsPercutaneous coronary interventionQuantitative flow ratioST-segment elevation myocardial infarctionVessel-oriented composite endpoint

Identifiers

PMID33044717
OpenAlexW3091923978

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.