Evidence map›Paper›PMID 33044868›Full record

ArticleAmerican journal of physiology. Renal physiology2020

A new mechanism for the sex differences in angiotensin II-induced hypertension: the role of macula densa NOS1β-mediated tubuloglomerular feedback.

Jie Zhang, Larry Qu, Jin Wei, Shan Jiang, Lan Xu, Lei Wang, Feng Cheng, Kun Jiang, Jacentha Buggs, Ruisheng Liu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Tubuloglomerular feedback: a key player in obesity-associated kidney injury.American journal of physiology. Renal physiology · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jie ZhangDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida.
Larry QuDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida.
Jin WeiDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida.
Shan JiangDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida.
Lan XuCollege of Public Health, University of South Florida, Tampa, Florida.
Lei WangDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida.
Feng ChengDepartment of Pharmaceutical Science, College of Pharmacy, University of South Florida, Tampa, Florida.
Kun JiangDepartment of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Jacentha BuggsAdvanced Organ Disease and Transplantation Institute, Tampa General Hospital, Tampa, Florida.
Ruisheng LiuDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida.ORCID 0000-0002-2220-1888
University of South Florida · USMoffitt Cancer Center · USTampa General Hospital · US

Funding

Role of tubuloglomerular feedback in the development of hypertension in diabetesR01HL142814 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI LIU, RUISHENG · 2019 to 2022
$2.4M
Renal hemodynamics and hypertension during pregnancyR01HL137987 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI LIU, RUISHENG · 2018 to 2021
$1.6M
Primary cilia and modulation of the renal microcirculationR01DK099276 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI LIU, RUISHENG · 2014 to 2017
$980k
HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI) HL137987HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI) HL142814HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK099276NHLBI NIH HHS R01 HL137987NHLBI NIH HHS R01 HL142814NIDDK NIH HHS R01 DK099276
6 · The paper itself

Abstract

Females are protected against the development of angiotensin II (ANG II)-induced hypertension compared with males, but the mechanisms have not been completely elucidated. In the present study, we hypothesized that the effect of ANG II on the macula densa nitric oxide (NO) synthase 1β (NOS1β)-mediated tubuloglomerular feedback (TGF) mechanism is different between males and females, thereby contributing to the sexual dimorphism of ANG II-induced hypertension. We used microperfusion, micropuncture, clearance of FITC-inulin, and radio telemetry to examine the sex differences in the changes of macula densa NOS1β expression and activity, TGF response, natriuresis, and blood pressure (BP) after a 2-wk ANG II infusion in wild-type and macula densa-specific NOS1 knockout mice. In wild-type mice, ANG II induced higher expression of macula densa NOS1β, greater NO generation by the macula densa, and a lower TGF response in vitro and in vivo in females than in males; the increases of glomerular filtration rate, urine flow rate, and Na

Indexed as

Sex CharacteristicsAngiotensin IIAnimalsFeedbackFemaleGlomerular Filtration RateHypertensionKidney CortexKidney GlomerulusKidney TubulesMaleMice, KnockoutNitric OxideNitric Oxide SynthaseNitric Oxide Synthase Type IAngiotensin IINitric OxideNitric Oxide SynthaseNitric Oxide Synthase Type Iangiotensin IIblood pressuresex differencetubuloglomerular feedback

Identifiers

PMID33044868
PMCPMC7789980
OpenAlexW3092389946

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.