ArticleAntimicrobial agents and chemotherapy2020
Comparison of Proteomic Responses as Global Approach to Antibiotic Mechanism of Action Elucidation.
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Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
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- Quantitative proteomic analysis reveals Ga(III) polypyridyl catecholate complexes disrupt Aspergillus fumigatus mitochondrial function.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2024Article
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- High Prevalence of Terbinafine Resistance Among Trichophyton mentagrophytes/T. interdigitale Species Complex, a Cross-Sectional Study from 2021 to 2022 in Northern Parts of Iran.Mycopathologia · 2024Article
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- Uncovering virulence factors inApplied and environmental microbiology · 2023Article
- Physiology of trans-translation deficiency in Bacillus subtilis - a comparative proteomics study.Proteomics · 2023Article
- No Chance to Survive:Antibiotics (Basel, Switzerland) · 2023Article
- Dual Action of Eeyarestatin 24 on Sec-Dependent Protein Secretion and Bacterial DNA.ACS infectious diseases · 2023Article
- New Insights into the Mechanism of Antibacterial Action of Synthetic PeptideAntibiotics (Basel, Switzerland) · 2022Article
- Clostridioides difficile Modifies its Aromatic Compound Metabolism in Response to Amidochelocardin-Induced Membrane Stress.mSphere · 2022Article
- Effects of 4-Br-A23187 on Bacillus subtilis cells and unilamellar vesicles reveal it to be a potent copper ionophore.Proteomics · 2022Article
- Expanding the search for small-molecule antibacterials by multidimensional profiling.Nature chemical biology · 2022Review
- Integrated genomics and chemical biology herald an era of sophisticated antibacterial discovery, from defining essential genes to target elucidation.Cell chemical biology · 2022Review
- Adaptive Responses ofAntimicrobial agents and chemotherapy · 2022Article
- The current state of SubtiWiki, the database for the model organism Bacillus subtilis.Nucleic acids research · 2022Article
- Myxopyronin B inhibits growth of a Fidaxomicin-resistant Clostridioides difficile isolate and interferes with toxin synthesis.Gut pathogens · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors at 9 institutions in 4 countries.
Christoph H R SengesApplied Microbiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
Jennifer J StepanekApplied Microbiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
Michaela WenzelApplied Microbiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
Nadja RaatschenApplied Microbiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
Ümran AyApplied Microbiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
Yvonne MärtensApplied Microbiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
Pascal ProchnowApplied Microbiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
Melissa Vázquez HernándezApplied Microbiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
Abdulkadir YayciApplied Microbiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
Britta SchubertApplied Microbiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
Niklas B M JanzingApplied Microbiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
Helen L WarmuthApplied Microbiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
Martin KozikApplied Microbiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
Jens BongardApplied Microbiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
John N AlumasaBiochemistry and Molecular Biology, Pennsylvania State University, State College, Pennsylvania, USA.
Bauke AlbadaBioinorganic Chemistry, Faculty of Chemistry and Biochemistry, Ruhr University Bochum, Bochum, Germany.
Maya PenkovaBioinorganic Chemistry, Faculty of Chemistry and Biochemistry, Ruhr University Bochum, Bochum, Germany.
Tadeja LukežičAcies Bio, Ljubljana, Slovenia.
Nohemy A SortoDepartment of Chemistry, University of California-Davis, Davis, California, USA.
Nicole LorenzBioinorganic Chemistry, Faculty of Chemistry and Biochemistry, Ruhr University Bochum, Bochum, Germany.
Reece G MillerBioinorganic Chemistry, Faculty of Chemistry and Biochemistry, Ruhr University Bochum, Bochum, Germany.
Bingyao ZhuDepartment of General Microbiology, Institute of Microbiology and Genetics, Georg-August University Göttingen, Göttingen, Germany.
Martin BendaDepartment of General Microbiology, Institute of Microbiology and Genetics, Georg-August University Göttingen, Göttingen, Germany.
Jörg StülkeDepartment of General Microbiology, Institute of Microbiology and Genetics, Georg-August University Göttingen, Göttingen, Germany.
Sina SchäkermannApplied Microbiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
Lars I LeichertMicrobial Biochemistry, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, Germany.
Kathi ScheinpflugPeptide Lipid Interactions, Leibniz Institute for Molecular Pharmacology, Berlin, Germany.
Heike Brötz-OesterheltMicrobial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine Tübingen, University of Tübingen, Tübingen, Germany.
Christian HertweckBiomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute, Jena, Germany.
Jared T ShawDepartment of Chemistry, University of California-Davis, Davis, California, USA.
Hrvoje PetkovićBiotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia.
Jean M BrunelUMR MD1, Membranes et Cibles Thérapeutiques, Faculté de Pharmacie U1261 INSERM, Aix-Marseille Université, Marseille, France.
Kenneth C KeilerBiochemistry and Molecular Biology, Pennsylvania State University, State College, Pennsylvania, USA.ORCID 0000-0001-8753-335X
Nils Metzler-NolteBioinorganic Chemistry, Faculty of Chemistry and Biochemistry, Ruhr University Bochum, Bochum, Germany.
Julia E BandowApplied Microbiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany julia.bandow@rub.de.ORCID 0000-0003-4100-8829
Ruhr University Bochum · DEUniversity of Göttingen · DEPennsylvania State University · USUniversity of California, Davis · USAcies Bio (Slovenia) · SIInserm · FRLeibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) · DEUniversity of Ljubljana · SIUniversity of Tübingen · DE
Funding
Physiology of ribosome rescue in bacteriaR01GM121650 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI KEILER, KENNETH C · 2017 to 2025
$3.8MNIGMS NIH HHS R01 GM121650
Abstract
New antibiotics are urgently needed to address the mounting resistance challenge. In early drug discovery, one of the bottlenecks is the elucidation of targets and mechanisms. To accelerate antibiotic research, we provide a proteomic approach for the rapid classification of compounds into those with precedented and unprecedented modes of action. We established a proteomic response library of
Indexed as
Anti-Bacterial AgentsProteomicsBacillus subtilisBacterial ProteinsTetracyclinesAnti-Bacterial AgentsBacterial ProteinsTetracyclinesantibioticchemical biologymechanism of actionphysiologyproteomics
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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.