Evidence map›Paper›PMID 33048222›Full record

Trial reportCancer immunology, immunotherapy : CII2021

Patients with gastrointestinal irritability after TGN1412-induced cytokine storm displayed selective expansion of gut-homing αβ and γδT cells.

Neil E McCarthy, Andrew J Stagg, Claire L Price, Elizabeth R Mann, Nichola L Gellatly, Hafid O Al-Hassi, Stella C Knight, Nicki Panoskaltsis

Open access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer immunology, immunotherapy : CII, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Are all cytokine storms the same?Cancer immunology, immunotherapy : CII · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Neil E McCarthyAntigen Presentation Research Group, Imperial College London, Northwick Park and St. Mark's Campus, London, UK. n.e.mccarthy@qmul.ac.uk.
Andrew J StaggAntigen Presentation Research Group, Imperial College London, Northwick Park and St. Mark's Campus, London, UK.
Claire L PriceAntigen Presentation Research Group, Imperial College London, Northwick Park and St. Mark's Campus, London, UK.
Elizabeth R MannAntigen Presentation Research Group, Imperial College London, Northwick Park and St. Mark's Campus, London, UK.
Nichola L GellatlyAntigen Presentation Research Group, Imperial College London, Northwick Park and St. Mark's Campus, London, UK.
Hafid O Al-HassiAntigen Presentation Research Group, Imperial College London, Northwick Park and St. Mark's Campus, London, UK.
Stella C KnightAntigen Presentation Research Group, Imperial College London, Northwick Park and St. Mark's Campus, London, UK.
Nicki PanoskaltsisAntigen Presentation Research Group, Imperial College London, Northwick Park and St. Mark's Campus, London, UK. nicki.panoskaltsis@emory.edu.ORCID http://orcid.org/0000-0001-8972-5697
St Mark's Hospital · GBQueen Mary University of London · GBGeorgia Institute of Technology · USUniversity of Manchester · GBUniversity of Wolverhampton · GB

Funding

Biotechnology and Biological Sciences Research Council BBS/E/F/000PR10353Biotechnology and Biological Sciences Research Council BBS/E/F/000PR10356Cancer Research UK C18928/A8548Medical Research Council MR/R008302/1
6 · The paper itself

Abstract

Following infusion of the anti-CD28 superagonist monoclonal antibody TGN1412, three of six previously healthy, young male recipients developed gastrointestinal irritability associated with increased expression of 'gut-homing' integrin β7 on peripheral blood αβT cells. This subset of patients with intestinal symptoms also displayed a striking and persistent expansion of putative Vδ2

Indexed as

AdultAntibodies, Monoclonal, HumanizedCD28 AntigensCytokine Release SyndromeCytokinesGastrointestinal DiseasesHumansLeukocytes, MononuclearMaleReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaYoung AdultAntibodies, Monoclonal, HumanizedCD28 AntigensCytokinesReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaTGN-1412Cytokine release syndromeCytokine stormImmune-related adverse events (irAEs)ImmunotherapyTGN1412Vδ2+ γδT cells

Identifiers

PMID33048222
PMCPMC7552579
OpenAlexW3092159216

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.