Evidence map›Paper›PMID 33055090›Full record

ArticleGenetics2020

A Conserved NRDE-2/MTR-4 Complex Mediates Nuclear RNAi in

Gang Wan, Jenny Yan, Yuhan Fei, Daniel J Pagano, Scott Kennedy

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Transposon Regulation in thebioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Analysis ofComputational and structural biotechnology journal · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Gang WanMinistry Of Education Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, China 510275.ORCID 0000-0002-5990-7438
Jenny YanDepartment of Genetics, Blavatnik Institute at Harvard Medical School, Boston, Massachusetts 02115.
Yuhan FeiDepartment of Genetics, Blavatnik Institute at Harvard Medical School, Boston, Massachusetts 02115.
Daniel J PaganoDepartment of Genetics, Blavatnik Institute at Harvard Medical School, Boston, Massachusetts 02115.
Scott KennedyDepartment of Genetics, Blavatnik Institute at Harvard Medical School, Boston, Massachusetts 02115 Kennedy@genetics.med.harvard.edu.ORCID 0000-0002-7974-8155
Boston VA Research Institute · USHarvard University · USNanjing Agricultural University · CN

Funding

Small Regulatory RNA Functions In The NucleusR01GM088289 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI KENNEDY, SCOTT G · 2009 to 2022
$4.4M
Genetics and Genomics PhD Training GrantT32GM096911 · NIGMS · HARVARD MEDICAL SCHOOL · PI KENNEDY, SCOTT G · 2011 to 2020
$2.5M
Spatiotemporal Regulation of Liquid-like Condensates in the GermlineR01GM132286 · NIGMS · HARVARD MEDICAL SCHOOL · PI KENNEDY, SCOTT G · 2019 to 2022
$1.4M
Vesicular Trafficking of RNA from the Soma to the GermlineF32GM125345 · NIGMS · HARVARD MEDICAL SCHOOL · PI PAGANO, DANIEL · 2017 to 2017
$59k
NIGMS NIH HHS F32 GM125345NIGMS NIH HHS R01 GM088289NIGMS NIH HHS R01 GM132286NIGMS NIH HHS T32 GM096911
6 · The paper itself

Abstract

Small regulatory RNAs, such as small interfering RNAs (siRNAs) and PIWI-interacting RNAs, regulate splicing, transcription, and genome integrity in many eukaryotes. In

Indexed as

AnimalsArgonaute ProteinsCaenorhabditis elegansCaenorhabditis elegans ProteinsConserved SequenceGene SilencingHEK293 CellsHumansProtein BindingRNA-Binding ProteinsRNA, MessengerRNA, Small InterferingArgonaute ProteinsCaenorhabditis elegans ProteinsHRDE-1 protein, C elegansNRDE-2 protein, C elegansRNA-Binding ProteinsRNA, MessengerRNA, Small InterferingNRDE-2/MTR-4nuclear RNAiSmall regulatory RNAs

Identifiers

PMID33055090
PMCPMC7768265
OpenAlexW3093438261

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.