Evidence map›Paper›PMID 33061489›Full record

ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2020

Association of Metabolic Syndrome and Hyperferritinemia in Patients at Cardiovascular Risk.

Ricardo José Tofano, Leticia Maria Pescinni-Salzedas, Eduardo Federighi Baisi Chagas, Claudia Rucco Penteado Detregiachi, Elen Landgraf Guiguer, Adriano Cressoni Araujo, Marcelo Dib Bechara, Claudio José Rubira, Sandra Maria Barbalho

Open access · goldAbstract read
In one paragraph

Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pomegranate (Nutrients · 2022
    Pooled it
  2. Observational
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Observational
  9. Antioxidants (Basel, Switzerland) · 2022
    Review
  10. Article
  11. Article
  12. The Relationship of Hyperferritinemia to Metabolism and Chronic Complications in Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ricardo José TofanoDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Marília, São Paulo, Brazil.ORCID 0000-0002-4375-0990
Leticia Maria Pescinni-SalzedasDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Marília, São Paulo, Brazil.
Eduardo Federighi Baisi ChagasPostgraduate Program in Structural and Functional Interactions in Rehabilitation, UNIMAR, Marília, São Paulo, Brazil.ORCID 0000-0001-6901-9082
Claudia Rucco Penteado DetregiachiPostgraduate Program in Structural and Functional Interactions in Rehabilitation, UNIMAR, Marília, São Paulo, Brazil.
Elen Landgraf GuiguerDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Marília, São Paulo, Brazil.ORCID 0000-0002-9930-9694
Adriano Cressoni AraujoDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Marília, São Paulo, Brazil.ORCID 0000-0002-5716-2444
Marcelo Dib BecharaDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Marília, São Paulo, Brazil.ORCID 0000-0002-0073-734X
Claudio José RubiraDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Marília, São Paulo, Brazil.ORCID 0000-0003-2753-7281
Sandra Maria BarbalhoDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), Marília, São Paulo, Brazil.ORCID 0000-0002-5035-876X
Universidade de Marília · BRFaculdade de Medicina de Marília · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate the association between parameters of hyperferritinemia (HF) and metabolic syndrome (MS) in patients at cardiovascular risk. PATIENTS AND

methodsThis is a cross-sectional analytical observational study that included 269 patients who attended a cardiology unit. Biochemical and anthropometric parameters were evaluated to identify the presence of HF and MS. The presence of MS was evaluated according to NCEP ATP III. Biochemical parameters (glycemia, triglycerides, HDL-c) were assessed according to the manufacturer's protocols. Anthropometric measurements and blood pressure measurements were made by a trained professional. The chi-square (

resultsOur results showed that 57% of men and 49.5% of women presented with MS; 44% of men and 11% of women presented with HF. The presence of MS and hypertriglyceridemia increase the probability of having HF by up to 2.1 and 1.88 times, respectively, while for male sex it is increased by 6.2 times. Patients with HF have higher values of C-reactive protein, ferritin, and transferrin saturation, regardless of the presence of MS. The linear regression analysis model indicated that the variables considered in this study explain less than 30% of the variation in ferritin and that the presence of MS in men is responsible for 22% of the variation in the probability of the occurrence of HF.

conclusionOur results show that hyperferritinemia is closely associated with the components of MS (positive correlation with glycemia, triglycerides levels, blood pressure, and waist circumference, and negative correlation with HDL-c values) in the studied population.

Indexed as

cardiovascular diseasehyperferritinemiairon overload syndromemetabolic syndrome

Identifiers

PMID33061489
PMCPMC7522598
OpenAlexW3089077499

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.