ArticleInternal and emergency medicine2021
Disorders of sodium balance and its clinical implications in COVID-19 patients: a multicenter retrospective study.
Article in Internal and emergency medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 4 of them syntheses that pooled it.
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Who cites it
50 citing papers in PubMed, 4 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Association of hypernatremia with mortality in patients with COVID-19: A systematic review and meta-analysis.Immunity, inflammation and disease · 2023Pooled it
- Electrolyte imbalances as poor prognostic markers in COVID-19: a systemic review and meta-analysis.Journal of endocrinological investigation · 2023Pooled it
- ENDOCRINOLOGY IN THE TIME OF COVID-19-2021 UPDATES: The management of diabetes insipidus and hyponatraemia.European journal of endocrinology · 2021Guideline
- The Prognostic Value of Hyponatremia for Predicting Poor Outcome in Patients With COVID-19: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Serum osmolarity as a predictor of mortality in ICU COVID-19 patients: a retrospective analysis.PeerJ · 2026Article
- Hyponatremia and the risk of sepsis in the setting of chronic kidney disease not on dialysis.Clinical kidney journal · 2025Article
- Assessment of electrolyte abnormalities in older adults with COVID-19 and delirium.SAGE open medicine · 2025Article
- Effect of Pituitary-Target Gland Axis on RAAS in the Context of COVID-19.International journal of medical sciences · 2025Review
- Syndrome of inappropriate antidiuresis/hyponatremia in COVID-19.Pituitary · 2024Review
- ICU-acquired hypernatremia: Prevalence, patient characteristics, trajectory, risk factors, and outcomes.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2024Article
- Editorial: Dysnatremias and related disorders.Frontiers in medicine · 2024Article
- Multisystem Inflammatory Syndrome in Children (MIS-C) Associated With COVID-19 Infection in Morocco.Global pediatric health · 2024Article
- Risk Factors for COVID-19 Infection in Adult Patients: A Retrospective Observational Study in Japan.Infection and drug resistance · 2024Article
- Observational
- Electrolytes and COVID-19: challenges and caveats in clinical research studies.Journal of nephrology · 2023Article
- Article
- Inappropriate therapy of euvolemic hyponatremia, the most frequent type of hyponatremia in SARS-CoV-2 infection, is associated with increased mortality in COVID-19 patients.Frontiers in endocrinology · 2023Article
- Article
- Which patients bring the most costs for hospital? A study on the cost determinants among COVID-19 patients in Iran.Cost effectiveness and resource allocation : C/E · 2022Article
- Comparison of trace element (selenium, iron), electrolyte (calcium, sodium), and physical activity levels in COVID-19 patients before and after the treatment.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2022Article
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe worldwide spread of SARS-CoV-2 has infected millions of people leading to over 0.3 million mortalities. The disruption of sodium homeostasis, tends to be a common occurrence in patients with COVID-19. METHODS AND
resultsA total of 1,254 COVID-19 patients comprising 124 (9.9%) hyponatremic patients (under 135 mmol/L) and 30 (2.4%) hypernatremic patients (over 145 mmol/L) from three hospitals in Hubei, China, were enrolled in the study. The relationships between sodium balance disorders in COVID-19 patients, its clinical features, implications, and the underlying causes were presented. Hyponatremia patients were observed to be elderly, had more comorbidities, with severe pneumonic chest radiographic findings. They were also more likely to have a fever, nausea, higher leukocyte and neutrophils count, and a high sensitivity C-reactive protein (HS-CRP). Compared to normonatremia patients, renal insufficiency was common in both hyponatremia and hypernatremia patients. In addition, hyponatremia patients required extensive treatment with oxygen, antibiotics, and corticosteroids. The only significant differences between the hypernatremia and normonatremia patients were laboratory findings and clinical complications, and patients with hypernatremia were more likely to use traditional Chinese medicine for treatment compared to normonatremia patients. This study indicates that severity of the disease, the length of stay in the hospital of surviving patients, and mortality were higher among COVID-19 patients with sodium balance disorders.
conclusionSodium balance disorder, particularly hyponatremia, is a common condition among hospitalized patients with COVID-19 in Hubei, China, and it is associated with a higher risk of severe illness and increased in-hospital mortality.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.