Evidence map›Paper›PMID 33066233›Full record

Trial reportCells2020

Gut Microbiome Changes in Patients with Active Left-Sided Ulcerative Colitis after Fecal Microbiome Transplantation and Topical 5-aminosalicylic Acid Therapy.

Dagmar Schierová, Jan Březina, Jakub Mrázek, Kateřina Olša Fliegerová, Simona Kvasnová, Lukáš Bajer, Pavel Drastich

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 4 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 4 syntheses or guidelines pooled it, 60 citations in OpenAlex.

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  18. Pharmaceuticals (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Dagmar SchierováInstitute of Animal Physiology and Genetics of the Czech Academy of Science, v.v.i., 142 20 Prague, Czech Republic.ORCID 0000-0001-9906-9072
Jan BřezinaHepatogastroenterology Department, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.
Jakub MrázekInstitute of Animal Physiology and Genetics of the Czech Academy of Science, v.v.i., 142 20 Prague, Czech Republic.ORCID 0000-0003-1907-3333
Kateřina Olša FliegerováInstitute of Animal Physiology and Genetics of the Czech Academy of Science, v.v.i., 142 20 Prague, Czech Republic.ORCID 0000-0001-9439-8168
Simona KvasnováInstitute of Animal Physiology and Genetics of the Czech Academy of Science, v.v.i., 142 20 Prague, Czech Republic.ORCID 0000-0002-2296-7795
Lukáš BajerHepatogastroenterology Department, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.ORCID 0000-0002-3815-3120
Pavel DrastichHepatogastroenterology Department, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.
Czech Academy of Sciences, Institute of Animal Physiology and Genetics · CZInstitute of Clinical and Experimental Medicine · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ulcerative colitis (UC) is an inflammatory bowel disease, and intestinal bacteria are implicated in the pathogenesis of this disorder. The administration of aminosalicylates (5-ASA) is a conventional treatment that targets the mucosa, while fecal microbial transplantation (FMT) is a novel treatment that directly targets the gut microbiota. The aim of this study was to identify changes in fecal bacterial composition after both types of treatments and evaluate clinical responses. Sixteen patients with active left-sided UC underwent enema treatment using 5-ASA (

Indexed as

Fecal Microbiota TransplantationGastrointestinal MicrobiomeAdministration, TopicalAdultAgedBacteriaBiodiversityColitis, UlcerativeDiscriminant AnalysisFecesFemaleHumansMaleMesalamineMiddle AgedPrincipal Component AnalysisMesalamine5-ASAfecal microbiome transplantationmicrobiomeulcerative colitis

Identifiers

PMID33066233
PMCPMC7602113
OpenAlexW3093159100

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.