Evidence map›Paper›PMID 33066622›Full record

ArticleNutrients2020

Dietary Fatty Acids in Postprandial Triglyceride-Rich Lipoproteins Modulate Human Monocyte-Derived Dendritic Cell Maturation and Activation.

Carlos Vazquez-Madrigal, Soledad Lopez, Elena Grao-Cruces, Maria C Millan-Linares, Noelia M Rodriguez-Martin, Maria E Martin, Gonzalo Alba, Consuelo Santa-Maria, Beatriz Bermudez, Sergio Montserrat-de la Paz

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Acyclic Diterpene Phytol from Hemp Seed Oil (Foods (Basel, Switzerland) · 2022
    Article
  8. Article
  9. Mechanisms of Atherosclerosis Induced by Postprandial Lipemia.Frontiers in cardiovascular medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Carlos Vazquez-MadrigalDepartment of Medical Biochemistry, Molecular Biology and Immunology, School of Medicine, Universidad de Sevilla, 41009 Seville, Spain.
Soledad LopezDepartment of Medical Biochemistry, Molecular Biology and Immunology, School of Medicine, Universidad de Sevilla, 41009 Seville, Spain.
Elena Grao-CrucesDepartment of Medical Biochemistry, Molecular Biology and Immunology, School of Medicine, Universidad de Sevilla, 41009 Seville, Spain.
Maria C Millan-LinaresDepartment of Food & Health, Instituto de la Grasa, CSIC, 41013 Seville, Spain.ORCID 0000-0002-5661-8366
Noelia M Rodriguez-MartinDepartment of Food & Health, Instituto de la Grasa, CSIC, 41013 Seville, Spain.
Maria E MartinDepartment of Cell Biology, Faculty of Biology, Universidad de Sevilla, 41012 Seville, Spain.ORCID 0000-0002-3204-1726
Gonzalo AlbaDepartment of Medical Biochemistry, Molecular Biology and Immunology, School of Medicine, Universidad de Sevilla, 41009 Seville, Spain.
Consuelo Santa-MariaDepartment of Biochemistry and Molecular Biology, School of Pharmacy, Universidad de Sevilla, 41012 Seville, Spain.
Beatriz BermudezDepartment of Cell Biology, Faculty of Biology, Universidad de Sevilla, 41012 Seville, Spain.
Sergio Montserrat-de la PazDepartment of Medical Biochemistry, Molecular Biology and Immunology, School of Medicine, Universidad de Sevilla, 41009 Seville, Spain.ORCID 0000-0001-5400-3192
Universidad de Sevilla · ESInstituto de la Grasa · ES

Funding

Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía US-1263458
6 · The paper itself

Abstract

Dietary fatty acids have been demonstrated to modulate systemic inflammation and induce the postprandial inflammatory response of circulating immune cells. We hypothesized that postprandial triglyceride-rich lipoproteins (TRLs) may have acute effects on immunometabolic homeostasis by modulating dendritic cells (DCs), sentinels of the immunity that link innate and adaptive immune systems. In healthy volunteers, saturated fatty acid (SFA)-enriched meal raised serum levels of granulocyte/macrophage colony-stimulating factor GM-CSF (SFAs > monounsaturated fatty acids (MUFAs) = polyunsaturated fatty acids (PUFAs)) in the postprandial period. Autologous TRL-SFAs upregulated the gene expression of DC maturation (

Indexed as

Cell DifferentiationMonocytesAdultB7-1 AntigenCells, CulturedDendritic CellsDietary FatsFatty AcidsFemaleGene ExpressionGranulocyte-Macrophage Colony-Stimulating FactorHomeostasisHumansInterleukin-3 Receptor alpha SubunitLipoproteinsMaleB7-1 AntigenCD80 protein, humanDietary FatsFatty AcidsGranulocyte-Macrophage Colony-Stimulating FactorIL3RA protein, humanInterleukin-3 Receptor alpha SubunitLipoproteinsOlive OilTriglycerideschylomicrondendritic cellsfatty acidsmyeloid lineageolive oilpostprandial statetriglyceride-rich lipoprotein

Identifiers

PMID33066622
PMCPMC7656296
OpenAlexW3093206583

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.