Evidence map›Paper›PMID 33069882›Full record

ReviewClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2022

Expert Panel Review on Nonalcoholic Fatty Liver Disease in Persons With Human Immunodeficiency Virus.

Jordan E Lake, Turner Overton, Susanna Naggie, Mark Sulkowski, Rohit Loomba, David E Kleiner, Jennifer C Price, Kara W Chew, Raymond T Chung, Kathleen E Corey

Abstract readReview
In one paragraph

Review in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Effects of Semaglutide on Muscle Structure and Function in the SLIM LIVER Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Trial
  5. Trial
  6. Article
  7. Older people living with HIV: a population with high prevalence and severity of metabolic dysfunction-associated steatotic liver disease ‒ A cross-sectional study.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Observational
  12. Noninvasive Markers of Hepatic Steatosis and Fibrosis Following Integrase Strand-Transfer Inhibitor Initiation in Women With HIV.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jordan E LakeDivision of Infectious Disease, University of Texas Health Sciences Center at Houston, Houston, Texas. Electronic address: Jordan.E.Lake@uth.tmc.edu.
Turner OvertonDivision of Infectious Disease, University of Alabama School of Medicine, Birmingham, Alabama.
Susanna NaggieDivision of Infections Disease, Duke University School of Medicine, Durham, North Carolina.
Mark SulkowskiDivision of Infectious Disease, Johns Hopkins School of Medicine, Baltimore, Maryland.
Rohit LoombaDivision of Gastroenterology, University of California San Diego School of Medicine, San Diego, California.
David E KleinerCenter for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Jennifer C PriceDivision of Gastroenterology, University of California San Francisco School of Medicine, San Francisco, California.
Kara W ChewDivision of Infectious Diseases, University of California Los Angeles School of Medicine, Los Angeles, California.
Raymond T ChungDivision of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Kathleen E CoreyDivision of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Funding

Clinical Operations for Laboratory of PathologyZIDBC010686 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CHINQUEE, JOSEPH · 2009 to 2025
$22.6M
Postmortem PathologyZICBC010685 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KLEINER, DAVID ERWIN · 2009 to 2025
$14.3M
Intramural NIH HHS ZID BC010686
6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD) affects 25% of adults in the general population and is a disease spectrum ranging from steatosis to nonalcoholic steatohepatitis (NASH) to end-stage liver disease. NAFLD is an independent risk factor for cardiovascular disease, diabetes mellitus, and all-cause mortality, and NASH cirrhosis is a frequent indication for liver transplantation. In persons with human immunodeficiency virus (PWH), chronic liver disease is the second leading cause of non-human immunodeficiency virus-related mortality. Between 20% and 63% of PWH have NASH, and 14% to 63% have NASH with fibrosis. However, little is known about the optimal diagnostic strategies, risk factors for, and treatment of NAFLD in PWH. Here, we review current data on and identify knowledge gaps in the epidemiology, pathophysiology, diagnosis, and management of NAFLD in PWH and highlight priorities for research.

Indexed as

End Stage Liver DiseaseHIV InfectionsNon-alcoholic Fatty Liver DiseaseHIVHumansLiverLiver CirrhosisAntiretroviral Therapy (ART)Human Immunodeficiency Virus (HIV)Nonalcoholic Fatty Liver Disease (NAFLD)Nonalcoholic Steatohepatitis (NASH)Persons With HIV (PWH)

Identifiers

PMID33069882
PMCPMC9069630

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.