Evidence map›Paper›PMID 33072115›Full record

ArticleFrontiers in immunology2020

IL-10-Dependent and -Independent Mechanisms Are Involved in the Cardiac Pathology Modulation Mediated by Fenofibrate in an Experimental Model of Chagas Heart Disease.

Jimena Rada, Martín Donato, Federico N Penas, Catalina Alba Soto, Ágata C Cevey, Azul V Pieralisi, Ricardo Gelpi, Gerardo A Mirkin, Nora B Goren

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Fenofibrate for COVID-19 and related complications as an approach to improve treatment outcomes: the missed key for Holy Grail.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Review
  6. Article
  7. Article
  8. New Insights Into Blue Light Phototherapy in ExperimentalFrontiers in cellular and infection microbiology · 2021
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jimena RadaDepartamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Martín DonatoDepartamento de Patología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Federico N PenasDepartamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Catalina Alba SotoDepartamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Ágata C CeveyDepartamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Azul V PieralisiDepartamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Ricardo GelpiDepartamento de Patología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Gerardo A MirkinDepartamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Nora B GorenDepartamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
University of Buenos Aires · ARInstituto de Investigaciones Biomédicas en Retrovirus y Sida · ARConsejo Nacional de Investigaciones Científicas y Técnicas · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IL-10 is an anti-inflammatory cytokine that plays a significant role in the modulation of the immune response in many pathological conditions, including infectious diseases. Infection with

Indexed as

AnimalsCells, CulturedChagas CardiomyopathyCreatine KinaseDisease Models, AnimalFenofibrateHumansHypolipidemic AgentsInterleukin-10Interleukin-17MiceMice, Inbred BALB CMice, KnockoutMyocardiumNuclear Receptor Subfamily 1, Group F, Member 3Trypanosoma cruziCreatine KinaseFenofibrateHypolipidemic AgentsInterleukin-10Interleukin-17Nuclear Receptor Subfamily 1, Group F, Member 3chronic chagasic cardiomyopathyfenofibrateIL-10 knockout miceinflammatory responseTrypanosoma cruzi

Identifiers

PMID33072115
PMCPMC7541836
OpenAlexW3088275200

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.