Evidence map›Paper›PMID 33075807›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2021

The Effects of Kisspeptin on Brain Response to Food Images and Psychometric Parameters of Appetite in Healthy Men.

Lisa Yang, Lysia Demetriou, Matthew B Wall, Edouard G Mills, Victoria C Wing, Layla Thurston, Caroline N Schaufelberger, Bryn M Owen, Ali Abbara, Eugenii A Rabiner and 2 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Trial
  5. Acute Effects of Kisspeptin Administration on Bone Metabolism in Healthy Men.The Journal of clinical endocrinology and metabolism · 2022
    Trial
  6. Trial
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Lisa YangDivision of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK.
Lysia DemetriouInvicro London, London, UK.
Matthew B WallInvicro London, London, UK.
Edouard G MillsDivision of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK.
Victoria C WingDivision of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK.
Layla ThurstonDivision of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK.
Caroline N SchaufelbergerInvicro London, London, UK.
Bryn M OwenDivision of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK.
Ali AbbaraDivision of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK.
Eugenii A RabinerInvicro London, London, UK.
Alexander N ComninosDivision of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK.
Waljit S DhilloDivision of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK.
Imperial College London · GBInvicro (United Kingdom) · GBImperial College Healthcare NHS Trust · GB

Funding

Department of Health CS-2018-18-ST2-002Department of Health RP-2014-05-001Medical Research Council MR/R000484/1Medical Research Council MR/T006242/1Wellcome Trust 105545/Z/14/Z
6 · The paper itself

Abstract

contextThe hormone kisspeptin has crucial and well-characterized roles in reproduction. Emerging data from animal models also suggest that kisspeptin has important metabolic effects including modulation of food intake. However, to date there have been no studies exploring the effects of kisspeptin on brain responses to food stimuli in humans.

objectiveThis work aims to investigate the effects of kisspeptin administration on brain responses to visual food stimuli and psychometric parameters of appetite, in healthy men.

designA double-blinded, randomized, placebo-controlled, crossover study was conducted.

participantsParticipants included 27 healthy, right-handed, eugonadal men (mean ± SEM: age 26.5 ± 1.1 years; body mass index 23.9 ± 0.4 kg/m2).

interventionParticipants received an intravenous infusion of 1 nmol/kg/h of kisspeptin or rate-matched vehicle over 75 minutes.

main outcome measuresMeasurements included change in brain activity on functional magnetic resonance imaging in response to visual food stimuli and change in psychometric parameters of appetite, during kisspeptin administration compared to vehicle.

resultsKisspeptin administration at a bioactive dose did not affect brain responses to visual food stimuli or psychometric parameters of appetite compared to vehicle.

conclusionsThis is the first study in humans investigating the effects of kisspeptin on brain regions regulating appetite and demonstrates that peripheral administration of kisspeptin does not alter brain responses to visual food stimuli or psychometric parameters of appetite in healthy men. These data provide key translational insights to further our understanding of the interaction between reproduction and metabolism.

Indexed as

AdultAppetiteBrainCross-Over StudiesDouble-Blind MethodFoodHealthy VolunteersHumansInfusions, IntravenousKisspeptinsMagnetic Resonance ImagingMaleNerve NetPhotic StimulationPsychometricsRewardKisspeptinsappetitebehaviorfMRIfoodkisspeptinreward

Identifiers

PMID33075807
PMCPMC7993584
OpenAlexW3092877266

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.