PCSK9 inhibitors × all-cause mortality

SynthesisThe Cochrane database of systematic reviews2020

PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease.

Amand F Schmidt et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedrandomised · 60,997 people · 2020

Randomised comparison

Reduced deaths

−13%−20% to −6%

Bigger than 4 in 10 for all-cause mortality

As reported

OR 0.87, 95% CI 0.80–0.94 · the paper's word: All-cause mortality

Randomised comparison

Reduced deaths

−17%−28% to −4%

Bigger than 5 in 10 for all-cause mortality

As reported

OR 0.83, 95% CI 0.72–0.96 · the paper's word: All-cause mortality

Randomised comparison

Reduced deaths

−14%−21% to −6%

Bigger than 4 in 10 for all-cause mortality

As reported

OR 0.86, 95% CI 0.79–0.94 · the paper's word: All-cause mortality

Randomised comparison

Reduced deaths

−27%−42% to −9%

Bigger than 8 in 10 for all-cause mortality

As reported

OR 0.73, 95% CI 0.58–0.91 · the paper's word: All-cause mortality

+6 more in the walkthrough ↓

Ten numbers in the abstract

the abstract, start to end

difference (RD) of -2% (odds ratio (OR) 0.87, 95% confidence interval (CI) 0.80 to 0.94; 10 studies, 23,868 participants; high-certainty evidence), decreased the risk of mortality (RD -1%; OR 0.83, 95% CI 0.72 to 0.96; 12 studies, 24,797 participants; high-certainty evidence), and MI (RD -2%; OR 0.86, 95% CI 0.79 to 0.94; 9 studies, 23,352 participants; high-certainty evidence) and for any stroke (RD 0%; OR 0.73, 95% CI 0.58 to 0.91; 8

evolocumab, for CVD, the RD was -2% (OR 0.84, 95% CI 0.78 to 0.91; 3 studies, 29,432 participants; high-certainty evidence); for mortality, RD was less than 1% (OR 1.04, 95% CI 0.91 to 1.19; 3 studies, 29,432 participants; high-certainty evidence); for MI, RD was -1% (OR 0.72, 95% CI 0.64 to 0.82; 3 studies, 29,432 participants; high-certainty evidence); and for any stroke RD was less than -1% (OR 0.79, 95% CI 0.65 to 0.94; 2

effects, for CVD, the RD was 1% (OR 1.37, 95% CI 0.65 to 2.87; 3

any CVD event RD was less than -1% (OR 0.66, 95% CI 0.14 to 3.04; 1 study,

← favours treatmentfavours comparator →
could be chance
All-cause mortality
OR 0.870.80–0.94
All-cause mortality
OR 0.830.72–0.96
All-cause mortality
OR 0.860.79–0.94
All-cause mortality
OR 0.730.58–0.91
All-cause mortality
OR 0.840.78–0.91
All-cause mortality
OR 1.040.91–1.19
All-cause mortality
OR 0.720.64–0.82
All-cause mortality
OR 0.790.65–0.94
All-cause mortality
OR 1.370.65–2.87
All-cause mortality
OR 0.660.23–1.85
PCSK9 inhibitorsAll-cause mortality

PCSK9 inhibitors × all-cause mortalityhelps?replicated

unlikelylikely
1.00not counted
← favours treatmentfavours comparator →
more certainless certain
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