Evidence map›Paper›PMID 33083794›Full record

ArticleAdvancements in journal of urology and nephrology2020

Liver Function Enzymes are Potential Predictive Markers for Kidney Allograft Dysfunction.

Alakesh Bera, Eric Russ, Rahul M Jindal, Maura A Watson, Robert Nee, Ofer Eidelman, John Karaian, Harvey B Pollard, Meera Srivastava

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advancements in journal of urology and nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Alakesh BeraDepartment of Anatomy, Physiology and Genetics, Uniformed Services University, Bethesda, MD, US.
Eric RussDepartment of Anatomy, Physiology and Genetics, Uniformed Services University, Bethesda, MD, US.
Rahul M JindalUSU-Walter Reed Department of Surgery, Uniformed Services University, Bethesda, MD, US.
Maura A WatsonDepartment of Medicine, Uniformed Services University Bethesda, MD, US.
Robert NeeDepartment of Medicine, Uniformed Services University Bethesda, MD, US.
Ofer EidelmanDepartment of Anatomy, Physiology and Genetics, Uniformed Services University, Bethesda, MD, US.
John KaraianDepartment of Anatomy, Physiology and Genetics, Uniformed Services University, Bethesda, MD, US.
Harvey B PollardDepartment of Anatomy, Physiology and Genetics, Uniformed Services University, Bethesda, MD, US.
Meera SrivastavaDepartment of Anatomy, Physiology and Genetics, Uniformed Services University, Bethesda, MD, US.
Uniformed Services University of the Health Sciences · US

Funding

NHLBI PROTEOMICS INITIATIVE-N01HV28187N01HV028187 · HV · HENRY M. JACKSON FOUNDATION · PI POLLARD, HARVEY BRUCE · 2002 to 2006
–
NHLBI NIH HHS N01 HV028187
6 · The paper itself

Abstract

introductionBiopsy of the allograft is the gold standard for assessing kidney allograft dysfunction. The aim of our pilot study was to identify serum biomarkers that could obviate the need for biopsy. MATERIALS AND

methodsWe conducted a study to identify the biomarkers in the serum from different groups of chronic kidney disease (CKD) patients and kidney transplanted patients vs. healthy individuals. The four groups (n=25 in each group) were as follows: 1) Patients with unstable kidney allograft transplants requiring biopsy for cause, 2) Patients with stable kidney allograft transplants, 3) Patients with CKD not on immunosuppressive therapy and, 4) healthy subjects. We measured the activity and level of serum alkaline phosphatase (ALP) and other liver enzymes (alanine transaminase (ALT) and aspartate transaminase (AST)) as potential serum biomarkers in acute allograft dysfunction.

resultsWe found that ALP correlated with allograft biopsy findings, liver function, and clinical outcomes and possibly graft survival. Additionally, AST and ALT were higher in patients with graft rejection compared to non-rejected and stable kidney transplants. Moreover, the low Pearson correlations (r- values) between ALP level with age (r=0.179), gender, body mass index (r=0.236), creatinine (r=0.044) or estimated glomerular filtration rate (r=0.048) suggest that ALP may be an independent biomarker which is relatively unaffected by other individual-level variables.

conclusionALP may be a putative biomarker to predict kidney allograft function and rejection. Data also indicated that liver function plays an important role for the overall success of kidney transplantation.

Indexed as

chronic kidney diseaseKidney allograft rejectionnon-invasive biomarkerSerum alkaline phosphatase

Identifiers

PMID33083794
PMCPMC7571418
OpenAlexW3093837344

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.