Evidence map›Paper›PMID 33086602›Full record

ReviewAntioxidants (Basel, Switzerland)2020

Mechanisms of Chronic Metabolic Stress in Arrhythmias.

Blake H Gowen, Michael V Reyes, Leroy C Joseph, John P Morrow

Open access · goldAbstract readReview
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Blake H GowenDepartment of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.
Michael V ReyesDepartment of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.
Leroy C JosephDepartment of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.
John P MorrowDepartment of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.ORCID 0000-0002-9264-5273
Columbia University · US

Funding

Molecular mechanisms of arrhythmia caused by high-fat dietR01HL136758 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MORROW, JOHN PEARCE · 2018 to 2022
$2.0M
NHLBI NIH HHS R01 HL136758NIH HHS National Heart, Lung, and Blood Institute: R01 HL136758
6 · The paper itself

Abstract

Cardiac arrhythmias are responsible for many cardiovascular disease-related deaths worldwide. While arrhythmia pathogenesis is complex, there is increasing evidence for metabolic causes. Obesity, diabetes, and chronically consuming high-fat foods significantly increase the likelihood of developing arrhythmias. Although these correlations are well established, mechanistic explanations connecting a high-fat diet (HFD) to arrhythmogenesis are incomplete, although oxidative stress appears to be critical. This review investigates the metabolic changes that occur in obesity and after HFD. Potential therapies to prevent or treat arrhythmias are discussed, including antioxidants.

Indexed as

antioxidantscardiac arrhythmiadiabeteshigh-fat diet (HFD)metabolismmitochondriamyocardiumobesity

Identifiers

PMID33086602
PMCPMC7603089
OpenAlexW3093088204

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.