ArticleScience advances2020
Urbanization and market integration have strong, nonlinear effects on cardiometabolic health in the Turkana.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Divergent biological consequences of APOE isoforms across industrialized and non-industrial environments.PLoS genetics · 2026Article
- Divergent Biological Consequences of APOE Isoforms Across Industrialized and Non-Industrial Environments.bioRxiv : the preprint server for biology · 2026Article
- Built environment is a key driver of cardiometabolic health in two Indigenous groups undergoing rapid lifestyle change.Evolution, medicine, and public health · 2026Article
- The Endocrinological Basis for Polycystic Ovary Syndrome: An Evolutionary Perspective.Endocrinology · 2025Review
- Urbanization exacerbates age-associated declines in cardiometabolic health in Turkana and Orang Asli.medRxiv : the preprint server for health sciences · 2025Article
- Chronic Stress and Severe Water Insecurity During the Historic 2022 Drought in Northern Kenya Were Associated With Inflammation Among Daasanach Seminomadic Pastoralists.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Physical Activity and Pregnancy Norms Among Daasanach Semi-Nomadic Pastoralist Women in Northern Kenya.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Wild capuchin monkeys as a model system for investigating the social and ecological determinants of ageing.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Disentangling social, environmental, and zoonotic transmission pathways of a gastrointestinal protozoan (Blastocystis spp.) in northeast Madagascar.American journal of biological anthropology · 2024Article
- The built environment is more predictive of cardiometabolic health than other aspects of lifestyle in two rapidly transitioning Indigenous populations.medRxiv : the preprint server for health sciences · 2024Article
- How market integration impacts human disease ecology.Evolution, medicine, and public health · 2024Article
- Misalignment of plastic and evolutionary responses of lifespan to novel carbohydrate diets.Royal Society open science · 2024Article
- Integrating the Thrifty Genotype and Evolutionary Mismatch Hypotheses to understand variation in cardiometabolic disease risk.Evolution, medicine, and public health · 2024Review
- Lifestyle and patterns of physical activity in Hadza foragers.American journal of biological anthropology · 2023Article
- Applying an evolutionary mismatch framework to understand disease susceptibility.PLoS biology · 2023Article
- Conceptual and analytical approaches for modelling the developmental origins of inequality.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Review
- The effects of lifestyle change on indicators of cardiometabolic health in semi-nomadic pastoralists.Evolution, medicine, and public health · 2023Article
- Orang Asli Health and Lifeways Project (OA HeLP): a cross-sectional cohort study protocol.BMJ open · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The "mismatch" between evolved human physiology and Western lifestyles is thought to explain the current epidemic of cardiovascular disease (CVD) in industrialized societies. However, this hypothesis has been difficult to test because few populations concurrently span ancestral and modern lifestyles. To address this gap, we collected interview and biomarker data from individuals of Turkana ancestry who practice subsistence-level, nomadic pastoralism (the ancestral way of life for this group), as well as individuals who no longer practice pastoralism and live in urban areas. We found that Turkana who move to cities exhibit poor cardiometabolic health, partially because of a shift toward "Western diets" high in refined carbohydrates. We also show that being born in an urban area independently predicts adult health, such that life-long city dwellers will experience the greatest CVD risk. By focusing on a substantial lifestyle gradient, our work thus informs the timing, magnitude, and evolutionary causes of CVD.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.