Evidence map›Paper›PMID 33087396›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2021

Mechanism of Diuresis and Natriuresis by Cannabinoids: Evidence for Inhibition of Na

Joseph K Ritter, Ashfaq Ahmad, Shobha Mummalaneni, Zdravka Daneva, Sara K Dempsey, Ningjun Li, Pin-Lan Li, Vijay Lyall

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. NaInternational journal of molecular sciences · 2024
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Joseph K RitterDepartments of Pharmacology and Toxicology (J.K.R., A.A., Z.D., S.K.D., N.L., P.-L.L.) and Physiology and Biophysics (S.M., V.L.), Virginia Commonwealth University, Richmond, Virginia jritter@vcu.edu.ORCID 0000-0003-4028-8654
Ashfaq AhmadDepartments of Pharmacology and Toxicology (J.K.R., A.A., Z.D., S.K.D., N.L., P.-L.L.) and Physiology and Biophysics (S.M., V.L.), Virginia Commonwealth University, Richmond, Virginia.
Shobha MummalaneniDepartments of Pharmacology and Toxicology (J.K.R., A.A., Z.D., S.K.D., N.L., P.-L.L.) and Physiology and Biophysics (S.M., V.L.), Virginia Commonwealth University, Richmond, Virginia.
Zdravka DanevaDepartments of Pharmacology and Toxicology (J.K.R., A.A., Z.D., S.K.D., N.L., P.-L.L.) and Physiology and Biophysics (S.M., V.L.), Virginia Commonwealth University, Richmond, Virginia.
Sara K DempseyDepartments of Pharmacology and Toxicology (J.K.R., A.A., Z.D., S.K.D., N.L., P.-L.L.) and Physiology and Biophysics (S.M., V.L.), Virginia Commonwealth University, Richmond, Virginia.
Ningjun LiDepartments of Pharmacology and Toxicology (J.K.R., A.A., Z.D., S.K.D., N.L., P.-L.L.) and Physiology and Biophysics (S.M., V.L.), Virginia Commonwealth University, Richmond, Virginia.
Pin-Lan LiDepartments of Pharmacology and Toxicology (J.K.R., A.A., Z.D., S.K.D., N.L., P.-L.L.) and Physiology and Biophysics (S.M., V.L.), Virginia Commonwealth University, Richmond, Virginia.
Vijay LyallDepartments of Pharmacology and Toxicology (J.K.R., A.A., Z.D., S.K.D., N.L., P.-L.L.) and Physiology and Biophysics (S.M., V.L.), Virginia Commonwealth University, Richmond, Virginia.
Virginia Commonwealth University · US

Funding

TRAINING IN THE PHARMACOLOGY OF ABUSED DRUGST32DA007027 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI William L. Dewey · 1985 to 2026
$14.7M
VCU Center for Drug Addiction ResearchP30DA033934 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI JOLENE J WINDLE · 2014 to 2026
$13.8M
Renal Medullary HIF Prolyl Hydroxylases and Salt Sensitivity of Blood PressureR01HL089563 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI LI, NINGJUN · 2007 to 2016
$3.4M
Lysosome dysfunction in podocytopathy and associated hypertensionR01DK120491 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI LI, PINLAN · 2018 to 2022
$2.4M
Renal sphingosine-1-phosphate receptor 1 in salt-sensitive hypertensionR01HL145163 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI LI, NINGJUN · 2019 to 2022
$1.6M
Renomedullary metabolism of anandamide and blood pressure regulationR01DK102539 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI LI, PINLAN, RITTER, JOSEPH K. · 2016 to 2019
$1.4M
Molecular mechanism of hypertension-induced renal injury: the role of HIF-1alphaR01DK107991 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI LI, NINGJUN · 2017 to 2019
$698k
Renomedullary metabolism of anandamide and blood pressure regulationR56DK102539 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI LI, PINLAN, RITTER, JOSEPH K. · 2014 to 2014
$92k
NHLBI NIH HHS R01 HL089563NHLBI NIH HHS R01 HL145163NIDA NIH HHS P30 DA033934NIDA NIH HHS T32 DA007027NIDDK NIH HHS R01 DK102539NIDDK NIH HHS R01 DK107991NIDDK NIH HHS R01 DK120491NIDDK NIH HHS R56 DK102539
6 · The paper itself

Abstract

The endocannabinoid, anandamide (AEA), stimulates cannabinoid receptors (CBRs) and is enriched in the kidney, especially the renal medulla. AEA infused into the renal outer medulla of mice stimulates urine flow rate and salt excretion. Here we show that these effects are blocked by the CBR type 1 (CB1) inverse agonist, rimonabant. Immunohistochemical analysis demonstrated the presence of CB1 in thick ascending limb (TAL) tubules. Western immunoblotting demonstrated the presence of CB1 (52 kDa) in the cortex and outer medulla of mouse kidney. The effect of direct [CP55940 (CP) or AEA] or indirect [fatty acyl amide hydrolase (FAAH) inhibitor, PF3845 (PF)] cannabinoidimetics on Na

Indexed as

DiuresisNatriuresisAmidohydrolasesAnimalsArachidonic AcidsCannabinoid Receptor AgonistsCannabinoid Receptor AntagonistsCyclohexanolsEndocannabinoidsFatty Acid Amide HydrolasesLoop of HenleMaleMiceMice, Inbred C57BLOuabainPiperidines3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanolAmidohydrolasesanandamideArachidonic AcidsCannabinoid Receptor AgonistsCannabinoid Receptor AntagonistsCyclohexanolsEndocannabinoidsFatty Acid Amide HydrolasesOuabainPF 3845PiperidinesPolyunsaturated AlkamidesPyridinesRimonabantSodiumSodium-Potassium-Exchanging ATPase

Identifiers

PMID33087396
PMCPMC7745087
OpenAlexW3093652497

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.