Evidence map›Paper›PMID 33092540›Full record

ArticleBMC medical genetics2020

Deep vein thrombosis inhibitor may play a therapeutic role in post-stroke patients.

Xixi Xiang, Di Yuan, Peiyan Kong, Ting Chen, Han Yao, Shijia Lin, Xi Zhang, Hongbao Cao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Xixi XiangState Key Laboratory of Trauma, Burns and Combined Injury; Medical Center of Hematology, The Second Affiliated Hospital of Army Medical University, Key Subject of Chongqing, No. 83 Xinqiao Street, Shapingba District, Chongqing, 400037, PR China.
Di YuanDepartment of Educational Technology, College of Basic Medical Sciences, Army Medical University, Chongqing, 400038, China.
Peiyan KongState Key Laboratory of Trauma, Burns and Combined Injury; Medical Center of Hematology, The Second Affiliated Hospital of Army Medical University, Key Subject of Chongqing, No. 83 Xinqiao Street, Shapingba District, Chongqing, 400037, PR China.
Ting ChenState Key Laboratory of Trauma, Burns and Combined Injury; Medical Center of Hematology, The Second Affiliated Hospital of Army Medical University, Key Subject of Chongqing, No. 83 Xinqiao Street, Shapingba District, Chongqing, 400037, PR China.
Han YaoState Key Laboratory of Trauma, Burns and Combined Injury; Medical Center of Hematology, The Second Affiliated Hospital of Army Medical University, Key Subject of Chongqing, No. 83 Xinqiao Street, Shapingba District, Chongqing, 400037, PR China.
Shijia LinState Key Laboratory of Trauma, Burns and Combined Injury; Medical Center of Hematology, The Second Affiliated Hospital of Army Medical University, Key Subject of Chongqing, No. 83 Xinqiao Street, Shapingba District, Chongqing, 400037, PR China.
Xi ZhangState Key Laboratory of Trauma, Burns and Combined Injury; Medical Center of Hematology, The Second Affiliated Hospital of Army Medical University, Key Subject of Chongqing, No. 83 Xinqiao Street, Shapingba District, Chongqing, 400037, PR China. zhangxxi@sina.com.ORCID 0000-0002-2533-8759
Hongbao CaoDepartment of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, 030001, Shanxi Province, China. caohon2010@gmail.com.
Army Medical University · CNGeorge Mason University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDeep vein thrombosis (DVT) is associated with stroke. Here, we hypothesize that genes associated with DVT may also play roles in the development of stroke.

methodswe firstly conducted large-scale literature based disease-gene relationship data analysis to explore the genes implicated with DVT and stroke. Further, a mega-analysis was conducted for each of these genes that were linked to DVT but not stroke, using 11 independent stroke RNA expression datasets (176 stroke cases and 102 healthy controls). Then, a multiple linear regression (MLR) model was employed to study possible influential factors on the gene expression levels in stroke. After that, a functional pathway analysis was performed to identify the potential biological linkage between stroke and the target genes suggested by mega-analysis.

resultsOver 81.10% genes implicated with DVT also suggested an association with stroke. Among the 24 DVT-specific genes, one DVT-inhibiting gene, SP1, presented significantly increased expression in stroke (LFC = 1.34, p-value = 0.0045). Pathway analysis showed that SP1 may play a therapeutic role in post-stroke patients by promoting multiple of stroke-inhibitors. Moreover, geographical region was indicated as an influential factor on the expression levels of SP1 in stroke samples (p-value = 0.037).

conclusionOur results suggested that DVT inhibitor SP1 could be a novel therapeutic target gene for post-stroke treatment. Further study of the potential relations between SP1 and stroke was guaranteed.

Indexed as

Databases, GeneticGene Expression ProfilingGenetic MarkersGenetic Predisposition to DiseaseHumansSp1 Transcription FactorStrokeStroke RehabilitationVenous ThrombosisGenetic MarkersSP1 protein, humanSp1 Transcription FactorDeep vein thrombosisMega-analysisMultiple linear regression analysisPathway analysisStroke

Identifiers

PMID33092540
PMCPMC7579790
OpenAlexW3094512103

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.