SynthesisThe European respiratory journal2021
A genome-wide association study of severe asthma exacerbations in Latino children and adolescents.
Open access · bronzeAbstract readMeta-Analysis
In one paragraph
Synthesis in The European respiratory journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Multi-ancestry genome-wide association study of asthma exacerbations.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Pooled it
- Genome-wide association study of asthma with high treatment burden and/or worse outcomes defined using electronic healthcare data in UK Biobank.ERJ open research · 2026Article
- KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Current understanding and future directions in severe asthma through artificial intelligence-integrated multi-omic approaches.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Pathway information on methylation analysis using deep neural network (PROMINENT): An interpretable deep learning method with pathway prior for phenotype prediction using gene-level DNA methylation.Artificial intelligence in medicine · 2025Article
- Chromosome 21 variants tied to severe asthma exacerbations: A genome-wide association study in a Brazilian population.The journal of allergy and clinical immunology. Global · 2025Article
- Omics approaches in asthma research: Challenges and opportunities.Chinese medical journal pulmonary and critical care medicine · 2024Review
- Progress and Gaps in Respiratory Disease Research and Treatment: Highlights of the IRM 2024 in Shanghai.Journal of respiratory biology and translational medicine · 2024Article
- Genetic risk prediction in Hispanics/Latinos: milestones, challenges, and social-ethical considerations.Journal of community genetics · 2023Review
- Asthma and Chronic Obstructive Pulmonary Disease.Clinics in chest medicine · 2023Review
- Airway transcriptome networks identify susceptibility to frequent asthma exacerbations in children.The Journal of allergy and clinical immunology · 2023Article
- T2DB: A Web Database for Long Non-Coding RNA Genes in Type II Diabetes.Non-coding RNA · 2023Article
- Asthma Exacerbations: The Genes Behind the Scenes.Journal of investigational allergology & clinical immunology · 2023Review
- Admixture mapping of severe asthma exacerbations in Hispanic/Latino children and youth.Thorax · 2023Article
- A whole genome sequencing study of moderate to severe asthma identifies a lung function locus associated with asthma risk.Scientific reports · 2022Article
- Asthma in the Americas: An Update: A Joint Perspective from the Brazilian Thoracic Society, Canadian Thoracic Society, Latin American Thoracic Society, and American Thoracic Society.Annals of the American Thoracic Society · 2022Review
- Targeted analysis of genomic regions enriched in African ancestry reveals novel classical HLA alleles associated with asthma in Southwestern Europeans.Scientific reports · 2021Article
- Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus.Genome medicine · 2021Article
- Respiratory and Neurological Disease across Different Ethnic Groups Is Influenced by the Microbiome.Microorganisms · 2021Review
- The Predictive Role of Biomarkers and Genetics in Childhood Asthma Exacerbations.International journal of molecular sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors at 10 institutions in 8 countries.
Qi YanDivision of Pediatric Pulmonary Medicine, University of Pittsburgh Medical Centre, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Erick FornoDivision of Pediatric Pulmonary Medicine, University of Pittsburgh Medical Centre, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0001-6497-9885
Esther Herrera-LuisGenomics and Health Group, Dept of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, La Laguna, Spain.
Maria Pino-YanesGenomics and Health Group, Dept of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, La Laguna, Spain.ORCID https://orcid.org/0000-0003-0332-437X
Cancan QiDept of Pediatric Pulmonology and Pediatric Allergy, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Raimon RiosInstituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil.ORCID https://orcid.org/0000-0002-3422-0453
Yueh-Ying HanDivision of Pediatric Pulmonary Medicine, University of Pittsburgh Medical Centre, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0002-8409-3077
Soyeon KimDivision of Pediatric Pulmonary Medicine, University of Pittsburgh Medical Centre, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Sam OhDept of Medicine, University of California San Francisco, San Francisco, CA, USA.
Edna Acosta-PérezBehavioral Sciences Research Institute, University of Puerto Rico, San Juan, Puerto Rico.
Rong ZhangDivision of Pediatric Pulmonary Medicine, University of Pittsburgh Medical Centre, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Donglei HuDept of Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID https://orcid.org/0000-0002-0351-001X
Celeste EngDept of Medicine, University of California San Francisco, San Francisco, CA, USA.
Scott HuntsmanDept of Medicine, University of California San Francisco, San Francisco, CA, USA.
Lydiana AvilaDept of Pediatrics, Hospital Nacional de Niños, San José, Costa Rica.
Nadia BoutaouiDivision of Pediatric Pulmonary Medicine, University of Pittsburgh Medical Centre, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Michelle M CloutierDept of Pediatrics, University of Connecticut, Farmington, CT, USA.
Manuel E Soto-QuirosDept of Pediatrics, Hospital Nacional de Niños, San José, Costa Rica.
Cheng-Jian XuCiiM and TWINCORE, joint ventures between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany.ORCID https://orcid.org/0000-0003-1586-4672
Scott T WeissChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0001-7196-303X
Jessica Lasky-SuChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Megan R KiedrowskiDept of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Camila FigueiredoInstituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil.
Jennifer BombergerDept of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Mauricio L BarretoInstituto de Saúde Coletiva, Federal University of Bahia, Salvador, Brazil.
Glorisa CaninoBehavioral Sciences Research Institute, University of Puerto Rico, San Juan, Puerto Rico.
Wei ChenDivision of Pediatric Pulmonary Medicine, University of Pittsburgh Medical Centre, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0001-7196-8703
Gerard H KoppelmanDept of Pediatric Pulmonology and Pediatric Allergy, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0001-8567-3252
Esteban G BurchardDept of Medicine, University of California San Francisco, San Francisco, CA, USA.
Juan C CeledónDivision of Pediatric Pulmonary Medicine, University of Pittsburgh Medical Centre, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA juan.celedon@chp.edu.
University of Pittsburgh · USUniversity of California, San Francisco · USUniversidade Federal da Bahia · BRBrigham and Women's Hospital · USHospital Nacional de Niños · CRUniversidad de La Laguna · ESUniversity Medical Center Groningen · NLUniversity of Puerto Rico System · PRRadboud University Nijmegen · NLUniversity of Connecticut · US
Funding
Systems Biology of Airway DiseaseP01HL132825 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISS, SCOTT T · 2016 to 2020
$12.6MThe Airway Functional Genomics of Bronchodilator Drug Response in Minority Children with AsthmaR01HL117004 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, SEIBOLD, MAX A · 2013 to 2022
$9.3MCLINICAL, PHARMACOLOGY, DRUG ACTION &PHARMACOKINETICST32GM007546 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Radojka Savic · 1985 to 2026
$8.9MSocial Interventions to address disparities In young adult tobacco useP60MD006902 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BIBBINS-DOMINGO, KIRSTEN · 2012 to 2016
$6.4MEpigenetic Variation and Childhood Asthma in Puerto RicansR01HL117191 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS · 2013 to 2020
$5.8MGene-environments and Admixture in Latino Asthmatics (GALA 2)R01ES015794 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$5.4MWhole Genome Analyses for Asthma in Latino PopulationsR01HL088133 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$3.8MGenes, Home Allergens and Asthma Puerto Rican ChildrenR01HL079966 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS · 2006 to 2010
$3.8MObesity and Childhood Asthma: The Role of Adipose TissueR01HL149693 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FORNO, ERICK · 2020 to 2024
$3.0MExposure to violence, epigenetic variation, and asthma in Puerto Rican childrenR01MD011764 · NIMHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS · 2017 to 2020
$1.3MNovel Methods for Analysis of Genetic and Epigenetic Studies of Childhood AsthmaK01HL138098 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YAN, QI · 2018 to 2022
$715kGenetics of Asthma In Latino AmericansK23HL004464 · NHLBI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2001 to 2005
$609kNHLBI NIH HHS K01 HL138098NHLBI NIH HHS K23 HL004464NHLBI NIH HHS P01 HL132825NHLBI NIH HHS R01 HL079966NHLBI NIH HHS R01 HL088133NHLBI NIH HHS R01 HL117004NHLBI NIH HHS R01 HL117191NHLBI NIH HHS R01 HL149693NIEHS NIH HHS R01 ES015794NIEHS NIH HHS R21 ES024844NIGMS NIH HHS T32 GM007546NIMHD NIH HHS P60 MD006902NIMHD NIH HHS R01 MD011764
Abstract
Severe asthma exacerbations are a major cause of school absences and healthcare costs in children, particularly those in high-risk racial/ethnic groups.To identify susceptibility genes for severe asthma exacerbations in Latino children and adolescents, we conducted a meta-analysis of genome-wide association studies (GWAS) in 4010 Latino youth with asthma in four independent cohorts, including 1693 Puerto Ricans, 1019 Costa Ricans, 640 Mexicans, 256 Brazilians and 402 members of other Latino subgroups. We then conducted methylation quantitative trait locus, expression quantitative trait locus and expression quantitative trait methylation analyses to assess whether the top single nucleotide polymorphism (SNP) in the meta-analysis is linked to DNA methylation and gene expression in nasal (airway) epithelium in separate cohorts of Puerto Rican and Dutch children and adolescents.In the meta-analysis of GWAS, an SNP in
Indexed as
AsthmaGenome-Wide Association StudyAdolescentBrazilChildHispanic or LatinoHumansPuerto Rico
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.