Evidence map›Paper›PMID 33093545›Full record

ArticleScientific reports2020

Phylogenetic and biochemical analysis of calsequestrin structure and association of its variants with cardiac disorders.

Qian Wang, Tautvydas Paskevicius, Alexander Filbert, Wenying Qin, Hyeong Jin Kim, Xing-Zhen Chen, Jingfeng Tang, Joel B Dacks, Luis B Agellon, Marek Michalak

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. How Functional Genomics Can Keep Pace With VUS Identification.Frontiers in cardiovascular medicine · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Qian WangDepartment of Biochemistry, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada.
Tautvydas PaskeviciusDepartment of Biochemistry, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada.
Alexander FilbertDivision of Infectious Disease, Department of Medicine, University of Alberta, Edmonton, AB, T6G 2G3, Canada.
Wenying QinInstitute of Biomedical and Pharmaceutical Sciences, Key Laboratory of Fermentation Engineering, Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, Hubei, China.
Hyeong Jin KimDepartment of Biochemistry, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada.
Xing-Zhen ChenInstitute of Biomedical and Pharmaceutical Sciences, Key Laboratory of Fermentation Engineering, Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, Hubei, China.
Jingfeng TangInstitute of Biomedical and Pharmaceutical Sciences, Key Laboratory of Fermentation Engineering, Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, Hubei, China.
Joel B DacksDivision of Infectious Disease, Department of Medicine, University of Alberta, Edmonton, AB, T6G 2G3, Canada. dacks@ualberta.ca.
Luis B AgellonSchool of Dietetics and Human Nutrition, McGill University, Ste. Anne de Bellevue, Quebec, H9X 3V9, Canada. luis.agellon@mcgill.ca.
Marek MichalakDepartment of Biochemistry, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada. marek.michalak@ualberta.ca.
University of Alberta · CAHubei University of Technology · CNMcGill University · CA

Funding

CIHR MOP-15291CIHR MOP-15415CIHR MOP-86750CIHR PS-153325
6 · The paper itself

Abstract

Calsequestrin is among the most abundant proteins in muscle sarcoplasmic reticulum and displays a high capacity but a low affinity for Ca

Indexed as

MutationPhylogenyAmino Acid SequenceAnimalsCalciumCalcium SignalingCalsequestrinHeart DiseasesHumansPhenotypeProtein ConformationSequence Homology, Amino AcidCalciumCalsequestrin

Identifiers

PMID33093545
PMCPMC7582152
OpenAlexW3094571323

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.