ArticleAlzheimer's & dementia (New York, N. Y.)2020
CCCDTD5 recommendations on early non cognitive markers of dementia: A Canadian consensus.
Article in Alzheimer's & dementia (New York, N. Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Summary of best evidence for non-pharmacological management of sleep disturbances in patients with mild cognitive impairment or early dementia: an integrative review.Frontiers in medicine · 2026Pooled it
- Dual-Task Gait as a Predictive Tool for Cognitive Impairment in Older Adults: A Systematic Review.Frontiers in aging neuroscience · 2021Pooled it
- Depressive and insomnia symptoms and incident dementia risk: A 12-year study in U.S. older adults.Journal of affective disorders · 2026Article
- [Early Alzheimer's disease recognition via multimodal hand movement quality assessment].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026Article
- Article
- Neuropsychiatric symptoms and gait/balance are predictors of functional trajectories in dementias.Dementia & neuropsychologia · 2026Article
- Dual-task, single challenge: functionality as an early marker of cognitive decline.Dementia & neuropsychologia · 2026Article
- Sensorized Motor and Cognitive Dual Task Framework for Dementia Diagnosis: Preliminary Insights From a Cross-Sectional Study.Journal of medical Internet research · 2025Article
- Motor-cognitive interactions in older adults: reliability and comparison of Trail Walking and Stepping Trail Making Tests.European geriatric medicine · 2025Article
- Differences in Finger Dexterity in Patients With Mild and Moderate Alzheimer's Disease-A Study of Cognitive Function by Disease Severity.Brain and behavior · 2025Article
- Updates and future perspectives on neuropsychiatric symptoms in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Gait Variability Is Associated With Gray Matter Volumes Implicated in Cognitive Function: A Cross-Sectional Analysis From the AGUEDA Trial.Innovation in aging · 2025Article
- Motor and Nonmotor Measures and Declining Daily Physical Activity in Older Adults.JAMA network open · 2024Article
- Balance, Strength, and Risk of Dementia: Findings From the Health and Retirement Study and the English Longitudinal Study of Ageing.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Progress on early diagnosing Alzheimer's disease.Frontiers of medicine · 2024Review
- Brain Networks Modulation during Simple and Complex Gait: A "Mobile Brain/Body Imaging" Study.Sensors (Basel, Switzerland) · 2024Article
- Link among apolipoprotein E E4, gait, and cognition in neurodegenerative diseases: ONDRI study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Postural Control Characteristics in Alzheimer's Disease, Dementia With Lewy Bodies, and Vascular Dementia.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Impact of Mild Behavioral Impairment on Longitudinal Changes in Cognition.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- The Australian Traumatic Brain Injury Initiative: Statement of Working Principles and Rapid Review of Methods to Define Data Dictionaries for Neurological Conditions.Neurotrauma reports · 2024Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCognitive impairment is the hallmark of Alzheimer's disease (AD) and related dementias. However, motor decline has been recently described as a prodromal state that can help to detect at-risk individuals. Similarly, sensory changes, sleep and behavior disturbances, and frailty have been associated with higher risk of developing dementia. These clinical findings, together with the recognition that AD pathology precedes the diagnosis by many years, raises the possibility that non-cognitive changes may be early and non-invasive markers for AD or, even more provocatively, that treating non-cognitive aspects may help to prevent or treat AD and related dementias.
methodsA subcommittee of the Canadian Consensus Conference on Diagnosis and Treatment of Dementia reviewed areas of emerging evidence for non-cognitive markers of dementia. We examined the literature for five non-cognitive domains associated with future dementia: motor, sensory (hearing, vision, olfaction), neuro-behavioral, frailty, and sleep. The Grading of Recommendations Assessment, Development, and Evaluation system was used to assign the strength of the evidence and quality of the recommendations. We provide recommendations to primary care clinics and to specialized memory clinics, answering the following main questions: (1) What are the non-cognitive and functional changes associated with risk of developing dementia? and (2) What is the evidence that sensory, motor, behavioral, sleep, and frailty markers can serve as potential predictors of dementia?
resultsEvidence supported that gait speed, dual-task gait speed, grip strength, frailty, neuropsychiatric symptoms, sleep measures, and hearing loss are predictors of dementia. There was insufficient evidence for recommending assessing olfactory and vision impairments as a predictor of dementia.
conclusionsNon-cognitive markers can assist in identifying people at risk for cognitive decline or dementia. These non-cognitive markers may represent prodromal symptoms and several of them are potentially amenable to treatment that might delay the onset of cognitive decline.
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